Document Detail

Lung lesions after combined inhalation of cobalt and nickel.
MedLine Citation:
PMID:  2004635     Owner:  NLM     Status:  MEDLINE    
Rabbits inhaled 0.5 mg/m3 Co2+ as CoCl2, a combination of 0.5 mg/m3 Co2+ as CoCl2 and 0.5 mg/m3 of Ni2+ as NiCl2, or filtered air (controls) for 4 months, 5 days/week, 6 hr/day. The pattern of morphological effects on lung tissue and alveolar macrophages after the simultaneous exposure to Co2+ and Ni2+ was a combination of the patterns seen after exposure to Co2+ and Ni2+ alone. However, nickel seemed to potentiate the specific effect of cobalt, i.e., the formation of noduli of type II cells. Further, the increase in phospholipids, especially in 1,2-dipalmitoylphosphatidylcholine, appeared more pronounced after the combined exposure than after the additive combination.
A Johansson; T Curstedt; P Camner
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Environmental research     Volume:  54     ISSN:  0013-9351     ISO Abbreviation:  Environ. Res.     Publication Date:  1991 Feb 
Date Detail:
Created Date:  1991-04-19     Completed Date:  1991-04-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0147621     Medline TA:  Environ Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  24-38     Citation Subset:  IM    
Section of Lung Medicine, Karolinska Institute, Stockholm, Sweden.
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MeSH Terms
Administration, Inhalation
Cobalt / administration & dosage,  toxicity*
Drug Synergism
Lung / chemistry
Macrophages / drug effects*,  ultrastructure
Microscopy, Electron
Microscopy, Electron, Scanning
Nickel / administration & dosage,  toxicity*
Phospholipids / analysis
Pulmonary Alveoli / drug effects*,  pathology,  ultrastructure
Reg. No./Substance:
0/Aerosols; 0/Phospholipids; 7440-02-0/Nickel; 7440-48-4/Cobalt

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