Document Detail


Lung lecithin biosynthesis in the nonhuman primate fetus: determination of the primary pathway in vivo.
MedLine Citation:
PMID:  8165     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The two pathways for de novo lecithin (phosphatidylcholine) biosynthesis, choline incorporation (1) and phosphatidylethanolamine methylation (II), were examined simultaneously in lung and other tissues of Rhesus monkey fetuses. Cannulation of interplacental fetal vessels permitted studies on the intrauterine fetus without disruption of fetal-placental-maternal-amniotic fluid anatomic integrity. In contrast to observations with indirect techniques in the same species, direct measurement of the incorporation of isotopic precursors (3H-choline and 14C-ethanolamine) into lecithin indicated that pathway I predominates by 100-fold over PE methylation in pulmonary lecithin synthesis. Fetal liver, brain, and kidney also showed 10--70-gold greater choline incorporation that methylation activity. Measurement of lung phosphatidylcholine production via the two pathways in acidemic fetuses (umbilical venous pH less than 7.20) demonstrated marked inhibition of pathway I, but not II. It is concluded that the choline pathway is the major mechanism of lung lecithin synthesis in fetal primates and that this pathway is pH sensitive in vivo.
Authors:
P M Farrell; M F Epstein; A R Fleischman; G K Oakes; R A Chez
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Biology of the neonate     Volume:  29     ISSN:  0006-3126     ISO Abbreviation:  Biol. Neonate     Publication Date:  1976  
Date Detail:
Created Date:  1976-10-20     Completed Date:  1976-10-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0247551     Medline TA:  Biol Neonate     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  238-46     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Acid-Base Equilibrium
Animals
Choline / metabolism
Ethanolamines / metabolism
Female
Fetus / metabolism*
Haplorhini
Hydrogen-Ion Concentration
Lung / metabolism*
Macaca mulatta
Phosphatidylcholines / biosynthesis*
Phosphatidylethanolamines / metabolism
Pregnancy
Chemical
Reg. No./Substance:
0/Ethanolamines; 0/Phosphatidylcholines; 0/Phosphatidylethanolamines; 62-49-7/Choline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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