| Lung ischemia-reperfusion injury: a molecular and clinical view on a complex pathophysiological process. | |
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MedLine Citation:
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PMID: 20833966 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Lung ischemia-reperfusion injury remains one of the major complications after cardiac bypass surgery and lung transplantation. Due to its dual blood supply system and the availability of oxygen from alveolar ventilation, the pathogenetic mechanisms of ischemia-reperfusion injury in the lungs are more complicated than in other organs, where loss of blood flow automatically leads to hypoxia. In this review, an extensive overview is given of the molecular and cellular mechanisms that are involved in the pathogenesis of lung ischemia-reperfusion injury and the possible therapeutic strategies to reduce or prevent it. In addition, the roles of neutrophils, alveolar macrophages, cytokines, and chemokines, as well as the alterations in the cell-death related pathways, are described in detail. |
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Authors:
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Willem A den Hengst; Jan F Gielis; Judy Y Lin; Paul E Van Schil; Leon J De Windt; An L Moens |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2010-09-10 |
Journal Detail:
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Title: American journal of physiology. Heart and circulatory physiology Volume: 299 ISSN: 1522-1539 ISO Abbreviation: Am. J. Physiol. Heart Circ. Physiol. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-11-01 Completed Date: 2010-11-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100901228 Medline TA: Am J Physiol Heart Circ Physiol Country: United States |
Other Details:
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Languages: eng Pagination: H1283-99 Citation Subset: IM |
Affiliation:
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Department of Thorax and Vascular Surgery, University of Antwerp, Antwerp, Belgium. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cardiopulmonary Bypass / adverse effects Humans Lung Diseases / physiopathology*, prevention & control, therapy Lung Transplantation / adverse effects Models, Animal Regional Blood Flow Reperfusion Injury / physiopathology*, prevention & control, therapy |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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