| Lung inflation distends small arteries (< 1 mm) in excised dog lungs. | |
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MedLine Citation:
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PMID: 8125879 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We utilized microfocal fluoroscopic angiography to study the influence of lung inflation on small (0.2- to 1.3-mm-diam) pulmonary arteries in isolated left lower lobes from dog lungs during both flow and no-flow conditions. Alveolar pressure, which in this preparation was equal to transpulmonary pressure, was set at 2, 8, or 14 mmHg while vascular pressure was varied from 0 to 24 mmHg. The diameters of these small arterial vessels increased with lung inflation. No differences were observed between the results obtained during flow and no-flow conditions. Thus, arteries in this diameter range can be considered as extra-alveolar, and the effect of lung inflation on these small extra-alveolar arteries was qualitatively similar to that previously described for larger extra-alveolar vessels. Quantitatively, the degree of vessel distension was about the same per unit increase in transpulmonary pressure at constant vascular pressure as for a change in vascular pressure at constant transpulmonary pressure. Accordingly, inflation produced a decrease in perivascular pressure surrounding these small arteries that was approximately equal to the increase in transpulmonary pressure. |
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Authors:
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R K Albert; W J Lamm; D A Rickaby; A al-Tinawi; C A Dawson |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: 75 ISSN: 8750-7587 ISO Abbreviation: J. Appl. Physiol. Publication Date: 1993 Dec |
Date Detail:
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Created Date: 1994-04-11 Completed Date: 1994-04-11 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 2595-601 Citation Subset: IM |
Affiliation:
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Department of Veterans Affairs Medical Center, Seattle, Washington. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Air Pressure Angiography Animals Arterioles / anatomy & histology, physiology Blood Pressure / physiology Dogs Lung / physiology* Lung Volume Measurements Pulmonary Artery / anatomy & histology, physiology* Respiratory Mechanics / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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HL-19298/HL/NHLBI NIH HHS; HL-24163-14S1A1/HL/NHLBI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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