Document Detail

Lung inflation distends small arteries (< 1 mm) in excised dog lungs.
MedLine Citation:
PMID:  8125879     Owner:  NLM     Status:  MEDLINE    
We utilized microfocal fluoroscopic angiography to study the influence of lung inflation on small (0.2- to 1.3-mm-diam) pulmonary arteries in isolated left lower lobes from dog lungs during both flow and no-flow conditions. Alveolar pressure, which in this preparation was equal to transpulmonary pressure, was set at 2, 8, or 14 mmHg while vascular pressure was varied from 0 to 24 mmHg. The diameters of these small arterial vessels increased with lung inflation. No differences were observed between the results obtained during flow and no-flow conditions. Thus, arteries in this diameter range can be considered as extra-alveolar, and the effect of lung inflation on these small extra-alveolar arteries was qualitatively similar to that previously described for larger extra-alveolar vessels. Quantitatively, the degree of vessel distension was about the same per unit increase in transpulmonary pressure at constant vascular pressure as for a change in vascular pressure at constant transpulmonary pressure. Accordingly, inflation produced a decrease in perivascular pressure surrounding these small arteries that was approximately equal to the increase in transpulmonary pressure.
R K Albert; W J Lamm; D A Rickaby; A al-Tinawi; C A Dawson
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  75     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1993 Dec 
Date Detail:
Created Date:  1994-04-11     Completed Date:  1994-04-11     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2595-601     Citation Subset:  IM    
Department of Veterans Affairs Medical Center, Seattle, Washington.
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MeSH Terms
Air Pressure
Arterioles / anatomy & histology,  physiology
Blood Pressure / physiology
Lung / physiology*
Lung Volume Measurements
Pulmonary Artery / anatomy & histology,  physiology*
Respiratory Mechanics / physiology*
Grant Support

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