Document Detail

Lung inflation distends small arteries (< 1 mm) in excised dog lungs.
MedLine Citation:
PMID:  8125879     Owner:  NLM     Status:  MEDLINE    
We utilized microfocal fluoroscopic angiography to study the influence of lung inflation on small (0.2- to 1.3-mm-diam) pulmonary arteries in isolated left lower lobes from dog lungs during both flow and no-flow conditions. Alveolar pressure, which in this preparation was equal to transpulmonary pressure, was set at 2, 8, or 14 mmHg while vascular pressure was varied from 0 to 24 mmHg. The diameters of these small arterial vessels increased with lung inflation. No differences were observed between the results obtained during flow and no-flow conditions. Thus, arteries in this diameter range can be considered as extra-alveolar, and the effect of lung inflation on these small extra-alveolar arteries was qualitatively similar to that previously described for larger extra-alveolar vessels. Quantitatively, the degree of vessel distension was about the same per unit increase in transpulmonary pressure at constant vascular pressure as for a change in vascular pressure at constant transpulmonary pressure. Accordingly, inflation produced a decrease in perivascular pressure surrounding these small arteries that was approximately equal to the increase in transpulmonary pressure.
R K Albert; W J Lamm; D A Rickaby; A al-Tinawi; C A Dawson
Related Documents :
6761039 - Edema formation in the newborn lung.
18714629 - The use of extracorporeal carbon dioxide removal in the management of life-threatening ...
19644409 - Combining "open-lung" ventilation and arteriovenous extracorporeal lung assist: influen...
9390969 - Isoproterenol attenuates high vascular pressure-induced permeability increases in isola...
4044179 - Mr imaging parameters in the study of lung water. a preliminary study.
24035939 - Effects of allium sativum (garlic) on systolic and diastolic blood pressure in patients...
2362259 - Stability of home blood pressure over time.
8433469 - Clinical utility and cost-effectiveness of an air suspension bed in the prevention of p...
17353979 - Experimental evaluation of the mechanical strength of stapling techniques.
Publication Detail:
Type:  In Vitro; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  75     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1993 Dec 
Date Detail:
Created Date:  1994-04-11     Completed Date:  1994-04-11     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2595-601     Citation Subset:  IM    
Department of Veterans Affairs Medical Center, Seattle, Washington.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Air Pressure
Arterioles / anatomy & histology,  physiology
Blood Pressure / physiology
Lung / physiology*
Lung Volume Measurements
Pulmonary Artery / anatomy & histology,  physiology*
Respiratory Mechanics / physiology*
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Effects of hyperoxia on maximal leg O2 supply and utilization in men.
Next Document:  Heart rate variability and fractal dimension during orthostatic challenges.