Document Detail

Lung immunoglobulins in the sudden infant death syndrome.
MedLine Citation:
PMID:  2492843     Owner:  NLM     Status:  MEDLINE    
The incidence of the sudden infant death syndrome parallels that of respiratory tract infections in the paediatric community. On the basis that the aetiology of the sudden infant death syndrome may lie in an unusual response to a trivial intercurrent respiratory infection a necropsy study was carried out investigating pulmonary immunoglobulins in 16 victims of the syndrome and a series of infants (controls) who had died of non-pulmonary causes. Compared with the controls victims of the sudden infant death syndrome had grossly raised concentrations of IgG, IgM, and to a less extent IgA in lung lavage samples. In addition, pulmonary interstitial and terminal airway cells expressing these immunoglobulins were identified far more often in victims than controls. The study failed to determine whether the increased immunoglobulin concentrations were a consequence of an unusual response to a trivial infection or an expression of otherwise altered immunological control in the respiratory tract. Epidemiological evidence and the findings of this study suggest that the respiratory tract is the prime target organ in the sudden infant death syndrome.
K D Forsyth; S C Weeks; L Koh; J Skinner; J Bradley
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  BMJ (Clinical research ed.)     Volume:  298     ISSN:  0959-8138     ISO Abbreviation:  BMJ     Publication Date:  1989 Jan 
Date Detail:
Created Date:  1989-04-03     Completed Date:  1989-04-03     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  8900488     Medline TA:  BMJ     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  23-6     Citation Subset:  AIM; IM    
Flinders University, South Australia.
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MeSH Terms
Bronchoalveolar Lavage Fluid / analysis
Immunoglobulin A / analysis*
Immunoglobulin G / analysis*
Immunoglobulin M / analysis*
Infant, Newborn
Lung / immunology*,  metabolism
Sudden Infant Death* / metabolism
Reg. No./Substance:
0/Immunoglobulin A; 0/Immunoglobulin G; 0/Immunoglobulin M

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