Document Detail

Lung growth and maturation in experimental oligohydramnios in the rat.
MedLine Citation:
PMID:  3670908     Owner:  NLM     Status:  MEDLINE    
On day 16 of gestation the amniotic sacs of either the right or left uterine horns of timed-pregnant Sprague-Dawley rats were punctured with a 20-gauge needle. The fetuses of the opposite horn served as controls. On day 21 of gestation (1 day prior to natural delivery), the fetuses were delivered by Cesarean section. Amniotic sac puncture resulted in a significant loss of amniotic fluid. Fetal growth retardation occurred. Lung growth was specifically retarded, as indicated by significantly reduced lung weight to body weight ratios and lung volume to body weight ratios following amniotic sac puncture. There appeared to be no effect on the structural units of the lung, since no differences between control and experimental fetal lungs were observed in terms of deoxyribonucleic acid, nonconnective tissue protein, total phospholipid, and disaturated phosphatidylcholine per gm dry lung weight. The ratios of disaturated phosphatidylcholine to total phospholipid and nonconnective tissue protein to deoxyribonucleic acid were unchanged. The volume proportions of saccular air, saccular wall, bronchial and bronchiolar air and nonparenchyma, peripheral airspace size, and surface-to-volume ratio were also unchanged. Thus loss of amniotic fluid significantly affected lung growth, more than it affected overall body growth, without having an effect on lung maturation.
K G Blachford; W M Thurlbeck
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pediatric pulmonology     Volume:  3     ISSN:  8755-6863     ISO Abbreviation:  Pediatr. Pulmonol.     Publication Date:    1987 Sep-Oct
Date Detail:
Created Date:  1987-12-17     Completed Date:  1987-12-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8510590     Medline TA:  Pediatr Pulmonol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  328-33     Citation Subset:  IM    
Department of Pathology, University of British Columbia, Faculty of Medicine, Vancouver, Canada.
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MeSH Terms
Amniotic Fluid*
Fetal Growth Retardation / etiology
Lung / growth & development*
Organ Size
Pregnancy Complications*
Rats, Inbred Strains

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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