Document Detail

Lung growth in newborn guinea pigs: effects of endurance exercise.
MedLine Citation:
PMID:  1410848     Owner:  NLM     Status:  MEDLINE    
Newborn Hartley albino guinea pigs were exercised daily on a rodent treadmill at 25 m/min, 0 degree grade for a maximum of 1 1/2 h. Groups were exercised for 1, 2 and 3 weeks. Controls were age-matched sedentary animals. A separate group of animals was sacrificed after 12 h of life to establish baseline lung growth data. A morphological and biochemical comparison was made between the lungs of exercised and sedentary animals. No effect of exercise on lung growth was observed. After 2 weeks of exercise animals had diminished somatic growth compared to the controls. The data was pooled from exercised and control guinea pigs at 1 and 3 weeks, at which time there were no differences, in order to obtain normal growth data. The only change between 0 week and 1 week was a slight increase in femur length. Between 1 week (and also 0 week) and 3 weeks there were significant increases in lung volume, lung weight, protein content, inter-alveolar wall distance, mean chord length of alveoli and ducts, and gas exchanging surface area. The guinea pig lung is well alveolated at birth and there was no evidence of subsequent alveolar multiplication. Enlargement of airspaces suggested that lung growth was primarily brought about by dilation. The lack of alveolar multiplication following exercise may be due to the fact the alveoli are fully developed at birth.
K A Ross; W M Thurlbeck
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Respiration physiology     Volume:  89     ISSN:  0034-5687     ISO Abbreviation:  Respir Physiol     Publication Date:  1992 Sep 
Date Detail:
Created Date:  1992-11-23     Completed Date:  1992-11-23     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0047142     Medline TA:  Respir Physiol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  353-64     Citation Subset:  IM    
Department of Academic Pathology, University of British Columbia, Vancouver, Canada.
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MeSH Terms
Age Factors
Animals, Newborn
Body Weight
Guinea Pigs
Lung / anatomy & histology,  growth & development*
Organ Size
Physical Endurance / physiology
Physical Exertion / physiology*
Pulmonary Alveoli / anatomy & histology,  growth & development

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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