| Lung function, permeability, and surfactant composition in oleic acid-induced acute lung injury in rats. | |
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MedLine Citation:
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PMID: 11076799 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Although acute lung injury (ALI) is associated with inflammation and surfactant dysfunction, the precise sequence of these changes remains poorly described. We used oleic acid to study the pathogenesis of ALI in spontaneously breathing anesthetized rats. We found that lung pathology can occur far more rapidly than previously appreciated. Lung neutrophils were increased approximately threefold within 5 min, and surfactant composition was dramatically altered within 15 min. Alveolar cholesterol increased by approximately 200%, and even though disaturated phospholipids increased by approximately 30% over 4 h, the disaturated phospholipid-to-total phospholipid ratio fell. Although the alveolocapillary barrier was profoundly disrupted after just 15 min, with marked elevations in lung fluid ((99m)Tc-labeled diethylenetriamine pentaacetic acid) and (125)I-labeled albumin flux, the lung rapidly began to regain its sieving properties. Despite the restoration in lung permeability, the animals remained hypoxic even though minute ventilation was increased approximately twofold and static compliance progressively deteriorated. This study highlights that ALI can set in motion a sequence of events continuing the respiratory failure irrespective of the alveolar surfactant pool size and the status of the alveolocapillary barrier. |
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Authors:
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K G Davidson; A D Bersten; H A Barr; K D Dowling; T E Nicholas; I R Doyle |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: American journal of physiology. Lung cellular and molecular physiology Volume: 279 ISSN: 1040-0605 ISO Abbreviation: Am. J. Physiol. Lung Cell Mol. Physiol. Publication Date: 2000 Dec |
Date Detail:
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Created Date: 2000-12-01 Completed Date: 2000-12-22 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 100901229 Medline TA: Am J Physiol Lung Cell Mol Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: L1091-102 Citation Subset: IM |
Affiliation:
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Department of Human Physiology, School of Medicine, Flinders University of South Australia, Australia. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Albumins
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pharmacokinetics Animals Blood Gas Analysis Body Fluid Compartments / physiology Bronchoalveolar Lavage Fluid / chemistry, cytology Capillary Permeability / physiology Iodine Radioisotopes / diagnostic use Leukocyte Count Lung Compliance / physiology* Lysophosphatidylcholines / metabolism Macrophages, Alveolar / cytology Male Oleic Acid* Organ Size Pneumonia / chemically induced, pathology, physiopathology Pulmonary Alveoli / metabolism, physiopathology* Rats Rats, Inbred Strains Respiratory Distress Syndrome, Adult / chemically induced, pathology, physiopathology* Surface-Active Agents / analysis*, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Albumins; 0/Iodine Radioisotopes; 0/Lysophosphatidylcholines; 0/Surface-Active Agents; 112-80-1/Oleic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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