| Lung function and late pulmonary complications among survivors of hematopoietic stem cell transplantation during childhood. | |
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MedLine Citation:
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PMID: 20416548 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hematopoietic stem cell transplantation (HSCT) is used to treat an expanding array of malignant and non-malignant disorders. Pulmonary complications represent a significant source of morbidity and mortality in HSCT recipients. Young children, whose lungs are still developing and growing, may be especially susceptible to the insults of irradiation, drug toxicities, and recurrent infections associated with immunosuppression. Late pulmonary complications, those occurring more than three months after transplantation, are often noninfectious and present with nonspecific symptomatology. Pulmonary function testing (PFT) is a mainstay of monitoring pulmonary health in HSCT recipients. The pulmonologist should be familiar with common patterns seen on PFT in recipients of HSCT during childhood. In this review, we describe the findings in studies which have examined lung function over time in patients who underwent HSCT during childhood. We discuss patterns of PFT abnormalities, associated noninfectious syndromes and their clinical implications, as well as directions for future research. |
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Authors:
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W Adam Gower; J Michael Collaco; Peter J Mogayzel |
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Publication Detail:
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Type: Journal Article; Review Date: 2010-04-09 |
Journal Detail:
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Title: Paediatric respiratory reviews Volume: 11 ISSN: 1526-0550 ISO Abbreviation: Paediatr Respir Rev Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-04-26 Completed Date: 2010-08-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100898941 Medline TA: Paediatr Respir Rev Country: England |
Other Details:
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Languages: eng Pagination: 115-22 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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Eudowood Division of Pediatric Respiratory Sciences, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Child Exercise Test Hematopoietic Stem Cell Transplantation / adverse effects* Humans Immunosuppressive Agents / adverse effects Lung Diseases / diagnosis, etiology*, physiopathology* Respiratory Function Tests Survivors |
| Chemical | |
Reg. No./Substance:
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0/Immunosuppressive Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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