Document Detail


Lung function in premature lambs and rabbits treated with a recombinant SP-C surfactant.
MedLine Citation:
PMID:  9476872     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We evaluated the efficacy of a recombinant surfactant protein-C (rSP-C) surfactant in vitro and in vivo, using ventilated preterm lambs and rabbits. The surface tension measured with a Wilhelmy balance of the rSP-C surfactant was lower than the surface tension of natural sheep surfactant (containing SP-B and SP-C). The rSP-C and natural surfactants were equivalently sensitive to inhibition by plasma. Over a 5-h study period, lambs treated with 100 mg/kg rSP-C and natural surfactants at birth had similar PCO2, lung mechanics, and FRC values. Indicators of injury also were not different. In preterm rabbits ventilated with 3 cm H2O positive end-expiratory pressure (PEEP), similar compliance responses were measured for the rSP-C and natural surfactant. Large-aggregate surfactants recovered from alveolar washes of the lambs treated with rSP-C or natural surfactant retained their function when tested in preterm rabbits. In conclusion, the rSP-C surfactant was effective in preterm animals with surfactant deficiency.
Authors:
A J Davis; A H Jobe; D Häfner; M Ikegami
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of respiratory and critical care medicine     Volume:  157     ISSN:  1073-449X     ISO Abbreviation:  Am. J. Respir. Crit. Care Med.     Publication Date:  1998 Feb 
Date Detail:
Created Date:  1998-03-12     Completed Date:  1998-03-12     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9421642     Medline TA:  Am J Respir Crit Care Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  553-9     Citation Subset:  AIM; IM    
Affiliation:
Department of Pediatrics, Harbor-UCLA Medical Center, UCLA School of Medicine, Torrance, California, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Newborn / physiology*
Gestational Age
Lung / drug effects*,  physiology*
Lung Compliance / drug effects
Positive-Pressure Respiration
Proteolipids / pharmacology*
Pulmonary Surfactants / pharmacology*
Rabbits
Recombinant Proteins
Respiration, Artificial
Sheep
Surface Tension
Grant Support
ID/Acronym/Agency:
HD-12714/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Proteolipids; 0/Pulmonary Surfactants; 0/Recombinant Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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