| Lung function in children and adolescents with juvenile idiopathic arthritis during long-term treatment with methotrexate: a retrospective study. | |
| | |
MedLine Citation:
|
PMID: 22409955 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
OBJECTIVES: Methotrexate may cause severe adverse pulmonary side-effects in adults with rheumatoid arthritis. Our aim was to examine the long-term effect of MTX on lung function in patients with juvenile idiopathic arthritis (JIA). METHODS: We retrospectively reviewed the charts of all 68 patients with JIA treated with MTX at our centre over a 14-year period. Results of annual pulmonary function tests (PFT) were compared using paired t-tests adjusted by Bonferroni correction and by linear regression analysis. RESULTS: The patients in our study had taken MTX for a median of 6.7 years with a median cumulative dose of 3219 mg. In a subgroup of 37 patients PFT had been performed before the onset of MTX. In this subgroup there was a significant decrease of mean mid-expiratory flow (MMEF) after 3 years (-14.0%, p<0.001) of MTX. Diffusion capacity of the lung for carbon monoxide (DLCO) was reduced after the third year (-12.4%, p=0.001). In the total group there was a decrease in MMEF between years 3 and 4 after MTX onset (-13.5%, p=0.001). Forced expiratory volume (FEV1) showed a slight rise between years 4 and 5 (+5.5%, p=0.003). All other parameters remained without significant changes. There was no correlation of PFT results and cumulative MTX dose or JIA subtype. None of our patients developed clinically relevant lung disease. CONCLUSIONS: In summary we found some declines of MMEF and DLCO during long-term treatment with MTX. Overall our data confirm the relative safety of long-term MTX treatment in patients with JIA. We conclude that further data on the development of pulmonary function in patients receiving MTX therapy would be helpful. |
| | |
Authors:
|
Christoph Leiskau; Angelika Thon; Monika Gappa; Frank Dressler |
Related Documents
:
|
23248535 - The short to medium-term risks of intracameral phenylephrine. 22513945 - Catheter ablation for paroxysmal and persistent atrial fibrillation. 20137365 - Immediate effects of acupuncture on gait patterns in patients with knee osteoarthritis. 23322265 - Sports involvement following acl reconstruction is related to lower extremity neuromusc... 11303975 - Multicentre comparative study of two schedules of gabexate mesilate in the treatment of... 19735875 - Artificial neural networks for prediction of response to chemoradiation in ht29 xenogra... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-3-9 |
Journal Detail:
|
Title: Clinical and experimental rheumatology Volume: - ISSN: 0392-856X ISO Abbreviation: - Publication Date: 2012 Mar |
Date Detail:
|
Created Date: 2012-3-13 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8308521 Medline TA: Clin Exp Rheumatol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Division of Pediatric Pneumology, Allergology and Neonatology, Dept. of Pediatrics, Hannover Medical School, Hannover, Germany. christoph-leiskau@gmx.de. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Diagnostic potential of Fasciola gigantica-derived 14.5 kDa fatty acid binding protein in the immun...
Next Document: Peak expiratory flow as a screening tool to detect airflow obstruction in a primary health care sett...