| Lung function in allogeneic bone marrow transplantation recipients. | |
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MedLine Citation:
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PMID: 2661259 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In order to investigate the incidence of pulmonary function complications following bone marrow transplantation (BMT), 17 patients with leukaemia and 8 with aplastic anaemia were sequentially assessed over a one year period. Before BMT, all the patients were free of respiratory symptoms and had both normal chest X-ray and routine lung function tests. However, 5 patients disclosed airway hyperreactivity. Aplastic anaemia patients had significantly lower haemoglobin-adjusted diffusing capacity for carbon monoxide (DLCO) than those with leukaemia, a finding significantly related to the lower haemoglobin values shown in the former individuals. Following BMT there were transient mild to moderate reductions in DLCO and static lung volumes; moreover, patients with leukaemia had lower DLCO than those with aplastic anaemia. Fourteen of the 25 patients had ventilatory defects, including 10 individuals with bronchial hyperresponsiveness. Post-BMT lung function changes were transiently accompanied by mild to moderate symptoms of respiratory disease in most of the patients. |
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Authors:
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R Rodríguez-Roisin; J Roca; A Grañena; A G Agustí; P Marín; C Rozman |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology Volume: 2 ISSN: 0903-1936 ISO Abbreviation: Eur. Respir. J. Publication Date: 1989 Apr |
Date Detail:
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Created Date: 1989-08-03 Completed Date: 1989-08-03 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8803460 Medline TA: Eur Respir J Country: DENMARK |
Other Details:
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Languages: eng Pagination: 359-65 Citation Subset: IM |
Affiliation:
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Dept. de Medicina, Facultat de Medicina, Universitat de Barcelona, Spain. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anemia, Aplastic / physiopathology, surgery Bone Transplantation* Cohort Studies Female Humans Leukemia / physiopathology, surgery Lung Diseases, Obstructive / epidemiology*, etiology, physiopathology Male Respiratory Function Tests Transplantation / adverse effects* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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