Document Detail


Lung function and bronchial hyper-responsiveness 11 years after hospitalization for bronchiolitis.
MedLine Citation:
PMID:  17880415     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIM: Atopic infants hospitalized for wheezing not caused by respiratory syncytial virus (RSV) carry the highest risk for later asthma. In the present paper, early risk factors for later lung function abnormalities and for bronchial hyper-responsiveness (BHR) were evaluated in 81 children, hospitalized for bronchiolitis in infancy, at the median age of 12.3 years. METHODS: The basic data, including data on atopy in children and viral aetiology of bronchiolitis, had been collected on entry to the study at less than 2 years of age. Lung function was studied by flow-volume spirometry (FVS), and BHR by methacholine and exercise challenge tests 11.4 years after hospitalization during infancy. RESULTS: RSV aetiology of bronchiolitis was associated with reduced forced vital capacity (FVC; 93.65% of predicted +/- 11.05 vs. 99.57%+/- 12.59, p = 0.009). Early sensitization to inhalant allergens (OR 12.59, 95% CI 2.30-68.77) and maternal smoking during pregnancy (OR 4.58, 95% CI 1.28-16.39) were associated with BHR to exercise, and early atopic dermatitis (OR 3.48, 95% CI 1.09-11.10) was associated with BHR to methacholine. CONCLUSIONS: RSV bronchiolitis was associated with a restrictive pattern of lung function. Early atopy and maternal smoking during pregnancy may play a role in the development and persistence of BHR.
Authors:
M K Hyvärinen; A Kotaniemi-Syrjänen; T M Reijonen; K Korhonen; M O Korppi
Related Documents :
16226985 - Adrenomedullin is up-regulated in nitrofen-induced fetal pulmonary hypoplasia.
12571135 - Temporary tracheal occlusion in fetal sheep with lung hypoplasia does not improve postn...
8185845 - Successful outcome in a case of cystic adenomatoid malformation of the lung complicated...
3335385 - Perinatal pulmonary hyperplasia due to laryngeal atresia.
23348165 - Maternal and neonatal outcome of controlled gestational diabetes mellitus versus high r...
16750625 - Evaluation of antifungal properties of octyl gallate and its synergy with cinnamaldehyde.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta paediatrica (Oslo, Norway : 1992)     Volume:  96     ISSN:  0803-5253     ISO Abbreviation:  Acta Paediatr.     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-09-20     Completed Date:  2008-01-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9205968     Medline TA:  Acta Paediatr     Country:  Norway    
Other Details:
Languages:  eng     Pagination:  1464-9     Citation Subset:  IM    
Affiliation:
Department of Paediatrics, Kuopio University and Kuopio University Hospital, Kuopio, Finland. ylinen@hytti.uku.fi
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adolescent
Bronchial Hyperreactivity / diagnosis*,  etiology
Bronchiolitis / complications,  physiopathology*
Child
Child, Preschool
Female
Health Status
Health Status Indicators
Hospitalization*
Humans
Infant
Infant, Newborn
Lung / physiology*
Male
Methacholine Chloride
Peak Expiratory Flow Rate
Prospective Studies
Respiratory Function Tests
Risk Factors
Spirometry
Time Factors
Vital Capacity
Chemical
Reg. No./Substance:
62-51-1/Methacholine Chloride
Comments/Corrections
Comment In:
Acta Paediatr. 2007 Oct;96(10):1387-8   [PMID:  17880410 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Successful breastfeeding after discharge of preterm and sick newborn infants.
Next Document:  Effects of ciclosporin A, tacrolimus and sirolimus on cytokine production in neonatal immune cells.