| Lung function and bronchial hyper-responsiveness 11 years after hospitalization for bronchiolitis. | |
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MedLine Citation:
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PMID: 17880415 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: Atopic infants hospitalized for wheezing not caused by respiratory syncytial virus (RSV) carry the highest risk for later asthma. In the present paper, early risk factors for later lung function abnormalities and for bronchial hyper-responsiveness (BHR) were evaluated in 81 children, hospitalized for bronchiolitis in infancy, at the median age of 12.3 years. METHODS: The basic data, including data on atopy in children and viral aetiology of bronchiolitis, had been collected on entry to the study at less than 2 years of age. Lung function was studied by flow-volume spirometry (FVS), and BHR by methacholine and exercise challenge tests 11.4 years after hospitalization during infancy. RESULTS: RSV aetiology of bronchiolitis was associated with reduced forced vital capacity (FVC; 93.65% of predicted +/- 11.05 vs. 99.57%+/- 12.59, p = 0.009). Early sensitization to inhalant allergens (OR 12.59, 95% CI 2.30-68.77) and maternal smoking during pregnancy (OR 4.58, 95% CI 1.28-16.39) were associated with BHR to exercise, and early atopic dermatitis (OR 3.48, 95% CI 1.09-11.10) was associated with BHR to methacholine. CONCLUSIONS: RSV bronchiolitis was associated with a restrictive pattern of lung function. Early atopy and maternal smoking during pregnancy may play a role in the development and persistence of BHR. |
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Authors:
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M K Hyvärinen; A Kotaniemi-Syrjänen; T M Reijonen; K Korhonen; M O Korppi |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Acta paediatrica (Oslo, Norway : 1992) Volume: 96 ISSN: 0803-5253 ISO Abbreviation: Acta Paediatr. Publication Date: 2007 Oct |
Date Detail:
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Created Date: 2007-09-20 Completed Date: 2008-01-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9205968 Medline TA: Acta Paediatr Country: Norway |
Other Details:
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Languages: eng Pagination: 1464-9 Citation Subset: IM |
Affiliation:
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Department of Paediatrics, Kuopio University and Kuopio University Hospital, Kuopio, Finland. ylinen@hytti.uku.fi |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Bronchial Hyperreactivity / diagnosis*, etiology Bronchiolitis / complications, physiopathology* Child Child, Preschool Female Health Status Health Status Indicators Hospitalization* Humans Infant Infant, Newborn Lung / physiology* Male Methacholine Chloride Peak Expiratory Flow Rate Prospective Studies Respiratory Function Tests Risk Factors Spirometry Time Factors Vital Capacity |
| Chemical | |
Reg. No./Substance:
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62-51-1/Methacholine Chloride |
| Comments/Corrections | |
Comment In:
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Acta Paediatr. 2007 Oct;96(10):1387-8
[PMID:
17880410
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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