Document Detail

Lung function and bronchial hyper-responsiveness 11 years after hospitalization for bronchiolitis.
MedLine Citation:
PMID:  17880415     Owner:  NLM     Status:  MEDLINE    
AIM: Atopic infants hospitalized for wheezing not caused by respiratory syncytial virus (RSV) carry the highest risk for later asthma. In the present paper, early risk factors for later lung function abnormalities and for bronchial hyper-responsiveness (BHR) were evaluated in 81 children, hospitalized for bronchiolitis in infancy, at the median age of 12.3 years. METHODS: The basic data, including data on atopy in children and viral aetiology of bronchiolitis, had been collected on entry to the study at less than 2 years of age. Lung function was studied by flow-volume spirometry (FVS), and BHR by methacholine and exercise challenge tests 11.4 years after hospitalization during infancy. RESULTS: RSV aetiology of bronchiolitis was associated with reduced forced vital capacity (FVC; 93.65% of predicted +/- 11.05 vs. 99.57%+/- 12.59, p = 0.009). Early sensitization to inhalant allergens (OR 12.59, 95% CI 2.30-68.77) and maternal smoking during pregnancy (OR 4.58, 95% CI 1.28-16.39) were associated with BHR to exercise, and early atopic dermatitis (OR 3.48, 95% CI 1.09-11.10) was associated with BHR to methacholine. CONCLUSIONS: RSV bronchiolitis was associated with a restrictive pattern of lung function. Early atopy and maternal smoking during pregnancy may play a role in the development and persistence of BHR.
M K Hyvärinen; A Kotaniemi-Syrjänen; T M Reijonen; K Korhonen; M O Korppi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta paediatrica (Oslo, Norway : 1992)     Volume:  96     ISSN:  0803-5253     ISO Abbreviation:  Acta Paediatr.     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-09-20     Completed Date:  2008-01-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9205968     Medline TA:  Acta Paediatr     Country:  Norway    
Other Details:
Languages:  eng     Pagination:  1464-9     Citation Subset:  IM    
Department of Paediatrics, Kuopio University and Kuopio University Hospital, Kuopio, Finland.
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MeSH Terms
Bronchial Hyperreactivity / diagnosis*,  etiology
Bronchiolitis / complications,  physiopathology*
Child, Preschool
Health Status
Health Status Indicators
Infant, Newborn
Lung / physiology*
Methacholine Chloride
Peak Expiratory Flow Rate
Prospective Studies
Respiratory Function Tests
Risk Factors
Time Factors
Vital Capacity
Reg. No./Substance:
62-51-1/Methacholine Chloride
Comment In:
Acta Paediatr. 2007 Oct;96(10):1387-8   [PMID:  17880410 ]

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