| Lung function and airway cytologic profiles in horses with recurrent airway obstruction maintained in low-dust environments. | |
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MedLine Citation:
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PMID: 17939565 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The effects of long-term environmental management on airway obstruction and inflammation in horses with recurrent airway obstruction (RAO) are unknown. HYPOTHESIS: Horses with RAO maintained in low-dust environments have persistent airway obstruction and neutrophilic inflammation. ANIMALS: Study horses were treated for RAO and then maintained in low-dust environments with no medical management. Horses were classified into 3 groups by years after diagnosis: 1 year (time 1, n = 9), 2-3 years (time 2, n = 7), and 5-6 years (time 3, n = 8). The comparison groups were age-matched healthy horses. METHODS: In this cross-sectional study, a clinical examination was performed, and the clinical score was calculated. Standard lung function, forced expiratory maneuvers, and the cytology of bronchoalveolar lavage fluid (BALF) were evaluated. RESULTS: The clinical scores of the RAO horses were higher than those of the non-RAO horses at time 2 (P = .018). Standard lung function data were not different between the groups at any time point. The forced expiratory flow between 75-95% of exhaled vital capacity was lower in RAO horses than in non-RAO horses at all time points (P < .02), indicating persistent peripheral airway obstruction. Cytologic evaluation of BALF revealed no difference in total nucleated cell numbers or differential cell counts between RAO and non-RAO horses at any time point. CONCLUSIONS AND CLINICAL IMPORTANCE: The peripheral airway obstruction detected in horses with RAO maintained in low-dust environments likely is due to irreversible airway remodeling but is not associated with cytologic evidence of airway inflammation. |
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Authors:
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M Miskovic; L L Couëtil; C A Thompson |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of veterinary internal medicine / American College of Veterinary Internal Medicine Volume: 21 ISSN: 0891-6640 ISO Abbreviation: J. Vet. Intern. Med. Publication Date: 2007 Sep-Oct |
Date Detail:
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Created Date: 2007-10-17 Completed Date: 2007-12-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8708660 Medline TA: J Vet Intern Med Country: United States |
Other Details:
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Languages: eng Pagination: 1060-6 Citation Subset: IM |
Affiliation:
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Purdue University School of Veterinary Medicine, West Lafayette, IN, USA. mmiskovi@purdue.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bronchoalveolar Lavage Fluid / cytology* Cross-Sectional Studies Dust Environment Female Forced Expiratory Volume Horse Diseases / pathology*, physiopathology Horses Male Pulmonary Disease, Chronic Obstructive / pathology, physiopathology, veterinary* Statistics, Nonparametric |
| Chemical | |
Reg. No./Substance:
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0/Dust |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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