Document Detail

Lung expansion in premature newborn rabbits treated with emulsified synthetic surfactant; principles for experimental evaluation of synthetic substitutes for pulmonary surfactant.
MedLine Citation:
PMID:  6566397     Owner:  NLM     Status:  MEDLINE    
This paper presents a sequence of tests for experimental evaluation of potential substitutes for pulmonary surfactant. Differential thermal analysis and the pulsating bubble technique were applied to identify an emulsified mixture of synthetic lipids with properties similar to those of natural surfactant. Instilled into the airways of premature newborn rabbits, this emulsion improved pulmonary pressure-volume characteristics and enhanced lung-thorax compliance during artificial ventilation. However, the in vivo effect was inferior to that of natural surfactant, especially as the emulsion failed to prevent the development of bronchiolar epithelial lesions.
G Grossmann; I Larsson; R Nilsson; B Robertson; L Rydhag; P Stenius
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Respiration; international review of thoracic diseases     Volume:  45     ISSN:  0025-7931     ISO Abbreviation:  Respiration     Publication Date:  1984  
Date Detail:
Created Date:  1984-10-24     Completed Date:  1984-10-24     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0137356     Medline TA:  Respiration     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  327-38     Citation Subset:  IM    
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MeSH Terms
Animals, Newborn
Cholesterol / administration & dosage
Drug Evaluation, Preclinical
Follow-Up Studies
Hyaline Membrane Disease / drug therapy*
Infant, Newborn
Lipids / administration & dosage*
Lung / pathology,  physiopathology*
Lung Compliance
Lysophosphatidylcholines / administration & dosage
Oils / administration & dosage
Phosphatidylglycerols / administration & dosage
Pulmonary Surfactants / administration & dosage
Surface Properties
Reg. No./Substance:
0/Emulsions; 0/Lipids; 0/Lysophosphatidylcholines; 0/Oils; 0/Phosphatidylglycerols; 0/Pulmonary Surfactants; 57-88-5/Cholesterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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