Document Detail


Lung epithelial wound healing in health and disease.
MedLine Citation:
PMID:  20923342     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Physiological lung epithelial wound repair is a complex, highly orchestrated process presenting numerous points where dysregulation may occur, leading to the development of several pulmonary disorders. Current studies are limited by a lack of relevant lung injury models, with much work relying on other organ models such as the skin or in vitro cultures. However, much promising investigative work is being undertaken, some of which is described in this article. This article attempts to describe the processes required to heal a severe wound to the airway epithelium, characteristic of several chronic pulmonary disorders, highlighting areas where dysregulation may occur, which in turn leads to the development or continuation of a disease state.
Authors:
Aaron Gardner; Lee A Borthwick; Andrew J Fisher
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Expert review of respiratory medicine     Volume:  4     ISSN:  1747-6356     ISO Abbreviation:  Expert Rev Respir Med     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-10-06     Completed Date:  2011-01-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101278196     Medline TA:  Expert Rev Respir Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  647-60     Citation Subset:  IM    
Affiliation:
Lung Immunobiology Group, Institute of Cellular Medicine, 4th Floor, William Leech Building, Medical School, Framlington Place, Newcastle University, NE2 4HH, UK.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Differentiation
Cell Proliferation
Extracellular Matrix / metabolism,  pathology
Humans
Lung Injury / immunology,  metabolism,  pathology*
Respiratory Mucosa / immunology,  metabolism,  pathology*
Signal Transduction
Wound Healing*
Grant Support
ID/Acronym/Agency:
G0700861//Medical Research Council

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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