Document Detail

Lung edema formation during cold perfusion: important differences between rat and porcine lung.
MedLine Citation:
PMID:  15812908     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The aim of this study was to investigate the effect of different perfusion pressures on edema formation during cold flush perfusion with the 2 most commonly used preservation solutions in clinical lung transplantation: Euro-Collins and Perfadex solutions. METHODS: Isolated rat and porcine lungs were perfused for 3 minutes at 4 degrees C to 8 degrees C at a pressure of either 10, 15 or 20 mm Hg. Weight gain was recorded continuously. Weight gain per minute was calculated after the first phase of rapid weight gain was completed. RESULTS: In the rat model, perfusion pressure of 10 mm Hg resulted in a macro- and microscopically apparent edema, irrespective of the type of preservation solution. Perfusion pressures of 10, 15 and 20 mm Hg have weight gains of 100%, 150% and 350%, respectively, after 3 minutes of perfusion. The corresponding weight gain per minute was 18%, 31% and 84% of the initial weight. There were no statistically significant differences in weight gain between the different solutions at equal perfusion pressure. In the porcine model the flow was extremely low at 10 mm Hg and no weight gain was registered, whereas the weight gain per minute at 15 and 20 mm Hg was 1.0% and 2.1% of the initial weight. CONCLUSIONS: In porcine lungs, cold perfusion at 20 mm Hg gives minimal edema formulation, whereas in rat lungs the edema formation is deleterious, irrespective of the solution used.
Per Wierup; Quiming Liao; Ramunas Bolys; Trygve Sjöberg; Bengt Rippe; Stig Steen
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation     Volume:  24     ISSN:  1053-2498     ISO Abbreviation:  J. Heart Lung Transplant.     Publication Date:  2005 Apr 
Date Detail:
Created Date:  2005-04-05     Completed Date:  2005-06-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9102703     Medline TA:  J Heart Lung Transplant     Country:  United States    
Other Details:
Languages:  eng     Pagination:  379-85     Citation Subset:  IM    
Department of Cardiothoracic Surgery, Skejby Hospital, Aarhus University Hospital, Denmark.
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MeSH Terms
Disease Models, Animal
Hypothermia, Induced / adverse effects*,  methods
Lung / blood supply,  pathology
Lung Transplantation / pathology
Organ Size
Pulmonary Circulation / physiology
Pulmonary Edema / etiology*,  pathology,  physiopathology
Random Allocation
Rats, Sprague-Dawley
Tissue Donors
Tissue Preservation / methods

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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