Document Detail

Lung diffusing capacity in a hyperbaric environment: assessment by a rebreathing technique.
MedLine Citation:
PMID:  1571296     Owner:  NLM     Status:  MEDLINE    
A rebreathing method was developed for measuring diffusing lung capacity for carbon monoxide (DLCO) in a hyperbaric environment. Twenty two professional naval divers with normal lung function were included in the study. Significant correlations were found between rebreathing and single breath measurements for DLCO (r = 0.94; p less than 0.001; standard error of the estimate (SEE) = 0.66), alveolar volume (VA) (r = 0.79; p less than 0.005; SEE = 0.51), and DLCO/VA (r = 0.83; p less than 0.001; SEE = 0.11). In 17 divers, rebreathing DLCO (DLCOrb) was also measured at 20 minutes pre-dive, during the first decompression stop of the dive to 45 m for 25 minutes, and at 10 minutes post-dive. Compressed air diving was performed in a dry walk-in chamber and the United States Navy decompression table was followed. The pressure induced decrease in the rate of CO binding to haemoglobin was adjusted to normobaric conditions using a theoretical approach. Also, the presence of venous bubbles post-dive was detected by precordial doppler monitoring. A biphasic change in DLCO was noted: initially, DLCO was increased during the dive (p less than 0.005); this was followed by a post-dive decrease; DLCO/VA changed in a similar manner, as VA was only slightly altered. Only a small post-dive precordial doppler bubble grade was found. In conclusion, rebreathing DLCO measurement is a useful respiratory function test in the hyperbaric environment. It appears that an increase in D(L)CO during the compressed air dive is related predominantly to increased pulmonary capillary blood volume caused by increased negativity of the pleural pressure, hyperoxic pulmonary vasodilatation, and cardiorespiratory centralisation of the blood. The decrease in D(L)CO post-dive was only partially related to the presence of the venous bubbles detectable by doppler.
Z Dujić; D Eterović; P Denoble; G Krstacić; J Tocilj
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British journal of industrial medicine     Volume:  49     ISSN:  0007-1072     ISO Abbreviation:  Br J Ind Med     Publication Date:  1992 Apr 
Date Detail:
Created Date:  1992-06-04     Completed Date:  1992-06-04     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0370637     Medline TA:  Br J Ind Med     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  254-9     Citation Subset:  IM; S    
Department of Physiology, Zagreb University School of Medicine in Split, Ribara, Republic of Croatia.
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MeSH Terms
Atmosphere Exposure Chambers
Blood Volume
Capillaries / physiology
Carbon Monoxide
Lung / blood supply
Pulmonary Diffusing Capacity / physiology*
Pulmonary Gas Exchange / physiology*
Reg. No./Substance:
630-08-0/Carbon Monoxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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