Document Detail

Lung development-the effects of chronic hypoxia.
MedLine Citation:
PMID:  12667825     Owner:  NLM     Status:  MEDLINE    
Chronic hypoxia compromises the development of both airways and pulmonary vasculature following exposure before or after birth. It also impairs adaptation to extrauterine life. The immediate morbidity and mortality is high, and long-term sequelae in terms of lung structure, and thus function, are common, particularly in premature infants. Chronic lung disease or bronchopulmonary dysplasia can develop with or without cor pulmonale. The extensive fibrotic disease of classical bronchopulmonary dysplasia has become uncommon with the development of improved treatment strategies, but the development of the lung periphery can still be compromised as more immature babies survive. This article highlights the landmarks of normal lung development together with the principal established and newly recognized features of exposure to chronic hypoxic in the young. In doing so, it indicates promising areas for research activity.
Sheila G Haworth; Alison A Hislop
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Seminars in neonatology : SN     Volume:  8     ISSN:  1084-2756     ISO Abbreviation:  Semin Neonatol     Publication Date:  2003 Feb 
Date Detail:
Created Date:  2003-04-01     Completed Date:  2003-07-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9606001     Medline TA:  Semin Neonatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1-8     Citation Subset:  IM    
Unit of Vascular Biology and Pharmacology, Institute of Child Health, University College London,30 Guilford Street, WC1N 1EH, London, UK.
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MeSH Terms
Anoxia / complications,  etiology,  physiopathology*
Chronic Disease
Fetal Hypoxia / etiology,  physiopathology
Infant, Newborn
Lung / blood supply*,  embryology,  growth & development*
Lung Diseases / etiology,  physiopathology
Smoking / adverse effects

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