| Lung development-the effects of chronic hypoxia. | |
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MedLine Citation:
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PMID: 12667825 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Chronic hypoxia compromises the development of both airways and pulmonary vasculature following exposure before or after birth. It also impairs adaptation to extrauterine life. The immediate morbidity and mortality is high, and long-term sequelae in terms of lung structure, and thus function, are common, particularly in premature infants. Chronic lung disease or bronchopulmonary dysplasia can develop with or without cor pulmonale. The extensive fibrotic disease of classical bronchopulmonary dysplasia has become uncommon with the development of improved treatment strategies, but the development of the lung periphery can still be compromised as more immature babies survive. This article highlights the landmarks of normal lung development together with the principal established and newly recognized features of exposure to chronic hypoxic in the young. In doing so, it indicates promising areas for research activity. |
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Authors:
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Sheila G Haworth; Alison A Hislop |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Seminars in neonatology : SN Volume: 8 ISSN: 1084-2756 ISO Abbreviation: Semin Neonatol Publication Date: 2003 Feb |
Date Detail:
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Created Date: 2003-04-01 Completed Date: 2003-07-02 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9606001 Medline TA: Semin Neonatol Country: England |
Other Details:
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Languages: eng Pagination: 1-8 Citation Subset: IM |
Affiliation:
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Unit of Vascular Biology and Pharmacology, Institute of Child Health, University College London,30 Guilford Street, WC1N 1EH, London, UK. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anoxia
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complications,
etiology,
physiopathology* Chronic Disease Female Fetal Hypoxia / etiology, physiopathology Humans Infant Infant, Newborn Lung / blood supply*, embryology, growth & development* Lung Diseases / etiology, physiopathology Pregnancy Smoking / adverse effects |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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