| Lung deposits of lipiodol in normal and cirrhotic rats. | |
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MedLine Citation:
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PMID: 1660296 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The distribution of Lipiodol in the liver and lungs following arterial or portal injection was studied in normal (n = 55) and cirrhotic rats (n = 20). Using magnified xeroradiography and radioisotope labeled tracers, it was found that Lipiodol was deposited mainly in the liver and lung after either arterial or portal administration. In control rats after arterial injection, deposits in the lung peaked after 2 hours and gradually declined over 48 hours; whereas after portal injection, the deposit steadily increased for 48 hours. Twenty-five percent of cirrhotic rats demonstrated a Lipiodol-induced military pattern in the lung. An increased number of portosystemic shunts in cirrhotic rats was also noted. These results suggest that cirrhosis of the liver may be a potential risk factor for developing pulmonary complications after Lipiodol administration. |
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Authors:
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J H Chiang; H C Cheng; M C Yang; J G Lo; C W Chi; W Y Lui; R S Liu; T Chang |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Acta radiologica (Stockholm, Sweden : 1987) Volume: 32 ISSN: 0284-1851 ISO Abbreviation: Acta Radiol Publication Date: 1991 Nov |
Date Detail:
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Created Date: 1992-01-15 Completed Date: 1992-01-15 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8706123 Medline TA: Acta Radiol Country: SWEDEN |
Other Details:
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Languages: eng Pagination: 474-8 Citation Subset: IM |
Affiliation:
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Department of Radiology, Veterans General Hospital-Taipei, Taiwan, Republic of China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arteriovenous Anastomosis Iodized Oil / administration & dosage, pharmacokinetics* Liver Cirrhosis, Experimental / metabolism* Lung / metabolism* Male Rats Rats, Inbred Strains Xeroradiography |
| Chemical | |
Reg. No./Substance:
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8001-40-9/Iodized Oil |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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