| Lung deposition of salbutamol in healthy human subjects from the MAGhaler dry powder inhaler. | |
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MedLine Citation:
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PMID: 12477219 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The MAGhaler (Mundipharma GmbH) is a multidose dry powder inhaler (DPI) containing a novel formulation of drug and lactose compacted by an isostatic pressing technique (GGU GmbH). On actuation, a precise dose is metered from a compacted ring-shaped drug tablet. In this study, the lung deposition of salbutamol from this device has been assessed. Ten healthy non-smoking subjects completed a two-way cross-over study assessing the pulmonary deposition of salbutamol (200 microg) from the MAGhaler at high (60 l/min) and low (30 l/min) peak inhaled flow rates (PIFRs), representing maximal and sub-maximal inspiratory efforts. The formulation was radiolabelled with 99mTc, and lung and oropharyngeal depositions were quantified by gamma scintigraphyThe mean (SD)% ofthe delivered dose deposited in the lungs was 26.4 (4.3)% at 60 l/min and 21.1 (5.1)% at 30 l/min (P < 0.05), corresponding to mean lung depositions of 52.8 and 42.2 microg salbutamol, respectively. The distribution of drug within different lung regions did not vary significantly with inhaled flow rate. The data provided proof of concept for the novel inhaler device and the innovative drug formulation. In comparison with previous deposition data obtained with other DPIs, the lung deposition was relatively high, relatively reproducible (coefficient of variation 16% at 60 l/min) and relatively insensitive to the change in peak inhaled flow rate. |
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Authors:
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S Newman; S Malik; R Hirst; G Pitcairn; A Heide; J Pabst; A Dinkelaker; W Fleischer |
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Publication Detail:
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Type: Clinical Trial; Evaluation Studies; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Respiratory medicine Volume: 96 ISSN: 0954-6111 ISO Abbreviation: Respir Med Publication Date: 2002 Dec |
Date Detail:
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Created Date: 2002-12-12 Completed Date: 2003-01-03 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8908438 Medline TA: Respir Med Country: England |
Other Details:
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Languages: eng Pagination: 1026-32 Citation Subset: IM |
Affiliation:
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Pharmaceutical Profiles Limited, Ruddington, Nottingham, U.K. snewman@pharmprofiles.co.uk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Albuterol / administration & dosage* Bronchodilator Agents / administration & dosage* Cross-Over Studies Drug Administration Schedule Female Humans Lung / drug effects*, radionuclide imaging Male Metered Dose Inhalers* Middle Aged Statistics, Nonparametric Technetium / diagnostic use |
| Chemical | |
Reg. No./Substance:
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0/Bronchodilator Agents; 18559-94-9/Albuterol; 7440-26-8/Technetium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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