| Lung deposition after inhalation with various nebulisers in preterm infants. | |
| | |
MedLine Citation:
|
PMID: 18192330 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
AIM: To compare pulmonary deposition after inhalation with three different nebulisers in preterm infants under conditions relevant to practice. METHODS: The relative lung deposition (bioavailability) was estimated by inhalation of the marker substance, sodium cromoglycate (SCG), and measurement of urinary excretion of SCG. Seventeen spontaneously breathing preterm infants received 20 mg of SCG as nebuliser solution by means of (a) an LC Star jet nebuliser; (b) an LS 290 ultrasonic nebuliser; and (c) a Projet ultrasonic nebuliser in a randomised three-period, crossover design. Serial urine samples were collected until about 12 hours after inhalations, and the excreted SCG was determined by high-performance liquid chromatography. RESULTS: The mean (SD) total amounts of SCG excreted in urine measured after inhalation with the LC Star nebuliser (0.089 (0.036) mg) were significantly higher than those obtained with the LS 290 (0.055 (0.019) mg) or the Projet nebuliser (0.046 (0.025) mg). The average pulmonary deposition after inhalation using the LC Star, LS 290 and Projet devices was estimated as 0.89%, 0.55% and 0.46% of the nominal dose, respectively. CONCLUSION: Inhalation with the LC Star jet nebuliser producing the greatest proportion of droplets <2 mum yielded a higher lung deposition in preterm infants than the LS 290 and Projet ultrasonic nebulisers. |
| | |
Authors:
|
E Köhler; G Jilg; S Avenarius; G Jorch |
Publication Detail:
|
Type: Journal Article; Randomized Controlled Trial Date: 2008-01-11 |
Journal Detail:
|
Title: Archives of disease in childhood. Fetal and neonatal edition Volume: 93 ISSN: 1468-2052 ISO Abbreviation: Arch. Dis. Child. Fetal Neonatal Ed. Publication Date: 2008 Jul |
Date Detail:
|
Created Date: 2008-06-23 Completed Date: 2008-09-26 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9501297 Medline TA: Arch Dis Child Fetal Neonatal Ed Country: England |
Other Details:
|
Languages: eng Pagination: F275-9 Citation Subset: AIM; IM |
Affiliation:
|
Department of Paediatrics, Medical Faculty, Otto von Guericke University, Magdeburg, Germany. elke.koehler@medizin.uni-magdeburg.de |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Administration, Inhalation Anti-Asthmatic Agents / administration & dosage, pharmacokinetics*, urine Cromolyn Sodium / administration & dosage, pharmacokinetics*, urine Female Humans Infant, Newborn Infant, Premature / metabolism*, urine Lung / metabolism* Male Nebulizers and Vaporizers |
| Chemical | |
Reg. No./Substance:
|
0/Anti-Asthmatic Agents; 15826-37-6/Cromolyn Sodium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Severe neonatal hypoxic respiratory failure correlates with histological chorioamnionitis and raised...
Next Document: Near-infrared reflectance analysis to evaluate the nitrogen and fat content of human milk in neonata...