Document Detail

Lung cyclic nucleotides in exercise-trained rats attenuate hypoxic pulmonary vasoconstriction.
MedLine Citation:
PMID:  8531499     Owner:  NLM     Status:  MEDLINE    
We examined the effects of exercise training on pulmonary arterial blood pressure (Ppa) and on adenosine 3',5'-cyclic monophosphate (cAMP) and guanosine 3',5'-cyclic monophosphate (GMP) concentrations in lung tissue at rest and during exercise under hypoxic conditions in catheter-implanted rats. Male Wistar rats were divided into an exercise-trained group (ET, n = 32) and nonexercised control group (control, n = 32). ET rats exercised 40 min/day 6 days/week for 6 weeks, at an altitude of 610 m on a treadmill. The mean Ppa levels of the ET were significantly lower than those of controls at rest and during exercise at 610- and 2500-m altitudes. The exercise-induced mean Ppa increase in the ET was less than that in controls at both 610- and 2500-m altitudes. Resting lung cAMP increased more in the ET than in controls at both 610- and 2500-m altitudes. In ET, cGMP was significantly greater at the 2500-m altitude than at the 610-m altitude at rest and just after exercise. Hypoxic exercise in ET was accompanied by a preferential increase in cGMP but not in cAMP. These results suggest that the intracellular augmentation of cAMP and cGMP in ET plays an important role in attenuating hypoxic pulmonary vasoconstriction (HPV) and exercise-induced increases in Ppa.
O Kashimura; A Sakai
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Lung     Volume:  173     ISSN:  0341-2040     ISO Abbreviation:  Lung     Publication Date:  1995  
Date Detail:
Created Date:  1996-01-31     Completed Date:  1996-01-31     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7701875     Medline TA:  Lung     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  363-72     Citation Subset:  IM    
Department of Sports Medicine, Shinshu University School of Medicine, Matsumoto, Japan.
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MeSH Terms
Anoxia / physiopathology
Blood Pressure / physiology
Cyclic AMP / metabolism,  physiology*
Cyclic GMP / metabolism,  physiology*
Heart Rate / physiology
Lung / metabolism*
Oxygen / physiology*
Physical Conditioning, Animal / physiology*
Pulmonary Circulation / physiology*
Rats, Wistar
Vasoconstriction / physiology*
Reg. No./Substance:
60-92-4/Cyclic AMP; 7665-99-8/Cyclic GMP; 7782-44-7/Oxygen

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