Document Detail

Lung compliance and lung morphology following artificial ventilation in the premature and full-term rabbit neonate.
MedLine Citation:
PMID:  394314     Owner:  NLM     Status:  MEDLINE    
Rabbit neonates delivered on day 27--30 of gestation were subjected to intermittent positive pressure ventilation (IPPV) for 60 min. Tidal volume was standardized to 10 ml/kg, and the insufflation pressure required to maintain this tidal volume was recorded. The quasistatic compliance of the lung-thorax system, corrected for variations in body weight, was significantly lower in animals delivered on day 27--28 than in those delivered on day 29--30. Immature animals with low lung-thorax compliance (less than 0.40 ml/cm regularly developed widespread necrosis of bronchiolar epithelium following IPPV, whereas no such lesions were observed in mature animals. It seems probable that these lesions are secondary to overdistension of bronchioles during IPPV and that this abnormal expansion pattern is related to a deficiency of surfactant in the lungs of immature newborn animals.
R Nilsson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Scandinavian journal of respiratory diseases     Volume:  60     ISSN:  0036-5572     ISO Abbreviation:  Scand J Respir Dis     Publication Date:  1979 Aug 
Date Detail:
Created Date:  1980-04-17     Completed Date:  1980-04-17     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0055427     Medline TA:  Scand J Respir Dis     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  206-14     Citation Subset:  IM    
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MeSH Terms
Animals, Newborn / physiology*
Body Weight
Bronchi / pathology
Epithelium / pathology
Gestational Age
Intermittent Positive-Pressure Ventilation / adverse effects*
Lung / pathology*
Lung Compliance*
Positive-Pressure Respiration / adverse effects*
Tidal Volume

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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