Document Detail

Lung compliance and alveolar expansion in the artificially ventilated premature newborn rabbit after maternal treatment with ambroxol.
MedLine Citation:
PMID:  7313347     Owner:  NLM     Status:  MEDLINE    
Premature newborn rabbits were delivered on day 27 of gestation, with or without antenatal treatment with ambroxol (50 mg/kg/day in maternal injections, on days 24-26). The animals were tracheostomized, kept in body plethysmographs at 35 degrees C, and ventilated artificially for 10 min with 100% oxygen, insufflation pressure 30 cm H2O, frequency 40/min, and varying inspiration time (20, 40, 60, or 80%). Lung-thorax compliance increased with inspiration time in both ambroxol-treated animals and controls, but there was no difference in compliance between treated and non-treated litters. Alveolar expansion, evaluated morphometrically in histological sections, was enhanced in ambroxol-treated animals ventilated with prolonged inspiration phase (60 or 80%); such a difference was not found in the on-treated group. This suggests that antenatal treatment with ambroxol might have a stimulating effect on the synthesis and/or release of factors improving alveolar stability in the premature lung.
B Lachmann; A B Tischer; G Grossmann; B Robertson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Respiration; international review of thoracic diseases     Volume:  42     ISSN:  0025-7931     ISO Abbreviation:  Respiration     Publication Date:  1981  
Date Detail:
Created Date:  1982-02-25     Completed Date:  1982-02-25     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0137356     Medline TA:  Respiration     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  209-16     Citation Subset:  IM    
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MeSH Terms
Ambroxol / pharmacology*
Animals, Newborn / physiology*
Bromhexine / analogs & derivatives*
Lung / analysis,  drug effects,  physiology
Lung Compliance / drug effects*
Maternal-Fetal Exchange
Pneumothorax / etiology
Pulmonary Alveoli / physiology*
Respiration, Artificial* / adverse effects
Thorax / physiology
Time Factors
Reg. No./Substance:
18683-91-5/Ambroxol; 3572-43-8/Bromhexine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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