Document Detail


Lung and chest wall mechanics in microgravity.
MedLine Citation:
PMID:  1761497     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We studied the effect of 15-20 s of weightlessness on lung, chest wall, and abdominal mechanics in five normal subjects inside an aircraft flying repeated parabolic trajectories. We measured flow at the mouth, thoracoabdominal and compartmental volume changes, and gastric pressure (Pga). In two subjects, esophageal pressures were measured as well, allowing for estimates of transdiaphragmatic pressure (Pdi). In all subjects functional residual capacity at 0 Gz decreased by 244 +/- 31 ml as a result of the inward displacement of the abdomen. End-expiratory Pga decreased from 6.8 +/- 0.8 cmH2O at 1 Gz to 2.5 +/- 0.3 cmH2O at Gz (P less than 0.005). Abdominal contribution to tidal volume increased from 0.33 +/- 0.05 to 0.51 +/- 0.04 at 0 Gz (P less than 0.001) but delta Pga showed no consistent change. Hence abdominal compliance increased from 43 +/- 9 to 70 +/- 10 ml/cmH2O (P less than 0.05). There was no consistent effect of Gz on tidal swings of Pdi, on pulmonary resistance and dynamic compliance, or on any of the timing parameters determining the temporal pattern of breathing. The results indicate that at 0 G respiratory mechanics are intermediate between those in the upright and supine postures at 1 G. In addition, analysis of end-expiratory pressures suggests that during weightlessness intra-abdominal pressure is zero, the diaphragm is passively tensed, and a residual small pleural pressure gradient may be present.
Authors:
J Edyvean; M Estenne; M Paiva; L A Engel
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  71     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1991 Nov 
Date Detail:
Created Date:  1992-02-07     Completed Date:  1992-02-07     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1956-66     Citation Subset:  IM; S    
Affiliation:
Thoracic Medicine Unit, Westmead Hospital, Sydney, New South Wales, Australia.
Space Flight Mission:
Flight Experiment; Parabolic Flight; manned; short duration
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MeSH Terms
Descriptor/Qualifier:
Abdomen
Functional Residual Capacity / physiology
Humans
Lung / physiology
Lung Volume Measurements
Male
Posture
Pressure
Respiratory Mechanics / physiology*
Thorax
Tidal Volume / physiology
Weightlessness / adverse effects*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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