Document Detail

Lung carcinoma of sheep (jaagsiekte): tissue-bound precipitating antibodies.
MedLine Citation:
PMID:  283268     Owner:  NLM     Status:  MEDLINE    
Firmly bound IgG was examined and its activity was tested in spontaneous lung carcinoma of sheep (jaagsiekte). High levels of IgG were extracted by acid-glycine buffer (GB) at pH 2.8 from both the tumor tissue and normal lung, which were exhaustively prewashed by phosphate-buffered saline (PBS) at pH 7.4. The first acid-GB eluates of the normal or tumor tissue acted in the immunodiffusion test as precipitating antibodies against antigens of the first PBS eluate of the tumor tissue. In addition, free intracytoplasmic type A particles were observed in cell-free tumor extract.
I Hod; R Milchan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of the National Cancer Institute     Volume:  62     ISSN:  0027-8874     ISO Abbreviation:  J. Natl. Cancer Inst.     Publication Date:  1979 Feb 
Date Detail:
Created Date:  1979-04-25     Completed Date:  1979-04-25     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7503089     Medline TA:  J Natl Cancer Inst     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  371-4     Citation Subset:  IM    
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MeSH Terms
Antibodies / isolation & purification*
Antibody Specificity
Immunoglobulin G
Inclusion Bodies, Viral
Lung / immunology
Pulmonary Adenomatosis, Ovine / immunology*,  pathology
Reg. No./Substance:
0/Antibodies; 0/Immunoglobulin G

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