| Lung cancer in patients with idiopathic pulmonary fibrosis. | |
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MedLine Citation:
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PMID: 11491167 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Idiopathic pulmonary fibrosis (IPF) was reported to be associated with increased risk of lung cancer as a result of the occurrence of atypical or dysplastic epithelial changes in fibrosis which progressed to invasive malignancy. In that situation, the cancer will develop in the area of major fibrosis. To investigate the direct relationship between fibrosis and cancer development, the real concordance rate of the two lesions in the chest computed tomography (CT) was analysed and compared to the histological types of lung cancer. The subjects included 63 patients with combined lung cancer and IPF (IPF-CA), 218 patients with lone IPF, and 2,660 patients with primary lung cancer. All patients were diagnosed at Asan Medical Center during the same period. The age, percentage of smokers, and the male sex were significantly higher in IPF-CA compared with lone IPF. The odds ratio of smoking was 2.71 compared to nonsmoking IPF controls. In IPF-CA, 56% of the cancer was located in the periphery of the lung and 52% in the upper lobe. The majority of the cancers (64%) were found in the nonfibrotic area at chest CT. The most frequent cell type was squamous cell carcinoma (35%), and there was no significant difference in the cancer cell type between IPF-CA and total lung cancer population. These findings suggest that in combined lung cancer and idiopathic pulmonary fibrosis patients, the features of the lung cancer are similar to the total lung cancer population. |
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Authors:
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J Park; D S Kim; T S Shim; C M Lim; Y Koh; S D Lee; W S Kim; W D Kim; J S Lee; K S Song |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology Volume: 17 ISSN: 0903-1936 ISO Abbreviation: Eur. Respir. J. Publication Date: 2001 Jun |
Date Detail:
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Created Date: 2001-08-08 Completed Date: 2001-12-18 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8803460 Medline TA: Eur Respir J Country: Denmark |
Other Details:
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Languages: eng Pagination: 1216-9 Citation Subset: IM |
Affiliation:
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Dept of Pulmonary Medicine, Asan Medical Center, School of Medicine, University of Ulsan, Seoul, Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Carcinoma, Non-Small-Cell Lung / pathology, radiography* Carcinoma, Small Cell / pathology, radiography* Cell Transformation, Neoplastic / pathology Female Humans Korea Lung / pathology, radiography Lung Neoplasms / pathology, radiography* Male Middle Aged Pulmonary Fibrosis / pathology, radiography* Retrospective Studies Risk Factors Tomography, X-Ray Computed* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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