Document Detail


Lung and brain damage in preterm newborns, and their association with gestational age, prematurity subgroup, infection/inflammation and long term outcome.
MedLine Citation:
PMID:  15715586     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Compared with those born at term, preterm newborns are at an increased risk of short term disorders of the lung (bronchopulmonary dysplasia; BPD) and the brain (white matter damage; WMD), and of long term developmental and pulmonary dysfunctions. Although all of these adverse outcomes are associated with low gestational age, brain, but not lung, damage appears to be associated with the prematurity subgroup [spontaneous preterm labour and/or preterm prelabour rupture of membranes (PPROM) vs pregnancy-induced hypertension (PIH)]. Part of the association between brain damage and prematurity subgroup might be due to a differential exposure of members of these subgroups to perinatal infection/inflammation. There is a lack of studies evaluating the association of antenatal and perinatal risk factors with late childhood pulmonary dysfunction among those born during the second trimester. In this paper we discuss the complexities that paediatricians, perinatologists and perinatal epidemiologists face as they try to understand the contributions of factors associated with preterm birth to neonatal and childhood disorders.
Authors:
Olaf Dammann; Alan Leviton; Monika Gappa; Christiane E L Dammann
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  BJOG : an international journal of obstetrics and gynaecology     Volume:  112 Suppl 1     ISSN:  1470-0328     ISO Abbreviation:  BJOG     Publication Date:  2005 Mar 
Date Detail:
Created Date:  2005-02-17     Completed Date:  2005-05-18     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  100935741     Medline TA:  BJOG     Country:  England    
Other Details:
Languages:  eng     Pagination:  4-9     Citation Subset:  AIM; IM    
Affiliation:
Perinatal Infectious Disease Epidemiology Unit, Department of Obstetrics and Pediatrics, OE 6415 Hannover Medical School, 30623 Hannover, Germany.
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MeSH Terms
Descriptor/Qualifier:
Brain Diseases / etiology*
Female
Humans
Infant, Newborn
Infant, Premature
Infant, Premature, Diseases / etiology*
Inflammation
Lung Diseases / etiology*
Pregnancy
Pregnancy Complications, Infectious
Pregnancy Outcome
Grant Support
ID/Acronym/Agency:
1U01 NS 40069-01A2/NS/NINDS NIH HHS; HL 004436/HL/NHLBI NIH HHS

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