| Lung and brain damage in preterm newborns, and their association with gestational age, prematurity subgroup, infection/inflammation and long term outcome. | |
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MedLine Citation:
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PMID: 15715586 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Compared with those born at term, preterm newborns are at an increased risk of short term disorders of the lung (bronchopulmonary dysplasia; BPD) and the brain (white matter damage; WMD), and of long term developmental and pulmonary dysfunctions. Although all of these adverse outcomes are associated with low gestational age, brain, but not lung, damage appears to be associated with the prematurity subgroup [spontaneous preterm labour and/or preterm prelabour rupture of membranes (PPROM) vs pregnancy-induced hypertension (PIH)]. Part of the association between brain damage and prematurity subgroup might be due to a differential exposure of members of these subgroups to perinatal infection/inflammation. There is a lack of studies evaluating the association of antenatal and perinatal risk factors with late childhood pulmonary dysfunction among those born during the second trimester. In this paper we discuss the complexities that paediatricians, perinatologists and perinatal epidemiologists face as they try to understand the contributions of factors associated with preterm birth to neonatal and childhood disorders. |
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Authors:
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Olaf Dammann; Alan Leviton; Monika Gappa; Christiane E L Dammann |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: BJOG : an international journal of obstetrics and gynaecology Volume: 112 Suppl 1 ISSN: 1470-0328 ISO Abbreviation: BJOG Publication Date: 2005 Mar |
Date Detail:
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Created Date: 2005-02-17 Completed Date: 2005-05-18 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 100935741 Medline TA: BJOG Country: England |
Other Details:
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Languages: eng Pagination: 4-9 Citation Subset: AIM; IM |
Affiliation:
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Perinatal Infectious Disease Epidemiology Unit, Department of Obstetrics and Pediatrics, OE 6415 Hannover Medical School, 30623 Hannover, Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Brain Diseases
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etiology* Female Humans Infant, Newborn Infant, Premature Infant, Premature, Diseases / etiology* Inflammation Lung Diseases / etiology* Pregnancy Pregnancy Complications, Infectious Pregnancy Outcome |
| Grant Support | |
ID/Acronym/Agency:
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1U01 NS 40069-01A2/NS/NINDS NIH HHS; HL 004436/HL/NHLBI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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