Document Detail


Lung aeration changes after lung recruitment in children with acute lung injury: a feasibility study.
MedLine Citation:
PMID:  22298419     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
RATIONALE: There are several adult studies using computed tomography (CT-scan) to examine lung aeration changes during or after a recruitment maneuver (RM) in ventilated patients with acute lung injury (ALI). However, there are no published data on the lung aeration changes during or after a RM in ventilated pediatric patients with ALI.
OBJECTIVE: To describe CT-scan lung aeration changes and gas exchange after lung recruitment in pediatric ALI and assess the safety of transporting patients in the acute phase of ALI to the CT-scanner.
METHODS: We present a case series completed in a subset of six patients enrolled in our previously published study of efficacy and safety of lung recruitment in pediatric patients with ALI.
INTERVENTION: RM using incremental positive end-expiratory pressure.
RESULTS: There was a variable increase in aerated and poorly aerated lung after the RM ranging from 3% to 72% (median 20%; interquartile range 6, 47; P = 0.03). All patients had improvement in the ratio of partial pressure of arterial oxygen over fraction of inspired oxygen (PaO(2) /FiO(2)) after the RM (median 14%; interquartile range: 8, 72; P = 0.03). There was a decrease in the partial pressure of arterial carbon dioxide (PaCO(2)) in four of six subjects after the RM (median -5%; interquartile range: -9, 2; P = 0.5). One subject had transient hypercapnia (41% increase in PaCO(2)) during the RM and this correlated with the smallest increase (3%) in aerated and poorly aerated lung. All patients tolerated the RM without hemodynamic compromise, barotrauma, hypoxemia, or dysrhythmias.
CONCLUSIONS: Lung recruitment results in improved lung aeration as detected by lung tomography. This is accompanied by improvements in oxygenation and ventilation. However, the clinical significance of these findings is uncertain. Transporting patients in early ALI to the CT-scanner seems safe and feasible.
Authors:
Juan P Boriosi; Ronald A Cohen; Evan Summers; Anil Sapru; James H Hanson; Ginny Gildengorin; Vivienne Newman; Heidi R Flori
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-02-01
Journal Detail:
Title:  Pediatric pulmonology     Volume:  47     ISSN:  1099-0496     ISO Abbreviation:  Pediatr. Pulmonol.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-07-12     Completed Date:  2012-12-04     Revised Date:  2014-10-19    
Medline Journal Info:
Nlm Unique ID:  8510590     Medline TA:  Pediatr Pulmonol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  771-9     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Wiley Periodicals, Inc.
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MeSH Terms
Descriptor/Qualifier:
Acute Lung Injury / radiography,  therapy*
Adolescent
Child, Preschool
Feasibility Studies
Female
Humans
Infant
Lung / physiopathology*,  radiography
Lung Volume Measurements
Male
Positive-Pressure Respiration / methods*
Pulmonary Gas Exchange
Tomography, X-Ray Computed
Grant Support
ID/Acronym/Agency:
K23 HL085526/HL/NHLBI NIH HHS; UL1RR024131-01/RR/NCRR NIH HHS
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