Document Detail


Lung Injury in Preterm Neonates: The Role and Therapeutic Potential of Stem Cells.
MedLine Citation:
PMID:  22400813     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Continuous improvements in perinatal care have allowed the survival of ever more premature infants, making the task of protecting the extremely immature lung from injury, increasingly challenging. Premature infants at risk of developing chronic lung disease or bronchopulmonary dysplasia (BPD) are now born at the late canalicular stage of lung development, just when the airways become juxtaposed to the lung vasculature and when gas-exchange becomes possible. Readily available strategies including improved antenatal management (education, regionalization, steroids, antibiotics) together with exogenous surfactant and exclusive/early non-invasive ventilatory support will likely decrease the incidence/severity of BPD over the next few years. Nonetheless, because of the extreme immaturity of the developing lung, the extent to which disruption of lung growth following prematurity and neonatal management lead to an earlier or more aggravated decline in respiratory function in later life is a matter of concern. Consequently, much more needs to be learned about the mechanisms of lung development, injury and repair. Recent insight into stem cell biology has sparked interest for stem cells to repair damaged organs. This review summarizes the exciting potential of stem cell-based therapies for lung diseases in general and BPD in particular.
Authors:
Rajesh Alphonse; Saima Rajabali; Bernard Thebaud
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-3-9
Journal Detail:
Title:  Antioxidants & redox signaling     Volume:  -     ISSN:  1557-7716     ISO Abbreviation:  -     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-3-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100888899     Medline TA:  Antioxid Redox Signal     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
University of Alberta, Department of Pediatrics and Women and Children Health Research Institute, University of Alberta, Edmonton, Alberta, Canada, Edmonton, Alberta, Canada; anthuvan@ualberta.ca.
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