Document Detail


Lung growth in infants and toddlers assessed by multi-slice computed tomography.
MedLine Citation:
PMID:  20542449     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
RATIONALE AND OBJECTIVES: Postnatal lung growth and development have primarily been evaluated from a very limited number of autopsied lungs, but it remains unclear whether alveolarization of the lung is complete during infancy and whether the conducting airways grow proportionately. The purpose of this study was to evaluate lung growth and development in vivo in infants and toddlers using multislice computed tomography.
MATERIALS AND METHODS: Thirty-eight subjects (14 male, 24 female) aged 17 to 142 weeks underwent low-dose volumetric high-resolution computed tomographic imaging at an inflation pressure of 20 cm H(2)O during an induced respiratory pause. Lung volume and weight were determined, as well as airway dimensions (inner and outer area and wall area) for the trachea and the next three to four generations.
RESULTS: Lung volume, air volume, and tissue volume increased linearly with body length. The air and tissue components of the lung parenchyma increased at a constant rate with each other. In addition, airway caliber decreased with increasing generation from the trachea into each lobe. Airway caliber was also correlated with body length; however, there was no interaction effect between airway generation and body length on transformed airway size.
CONCLUSIONS: In vivo assessment suggests that the growth of the lung parenchyma in infants and toddlers occurred with a constant relationship between air volume and lung tissue, which is consistent with lung growth occurring primarily by the addition of alveoli rather than the expansion of alveoli. In addition, the central conducting airways grow proportionately in infants and toddlers. This information may be important for evaluating subjects with arrested lung development.
Authors:
Laxmi Rao; Christina Tiller; Cathy Coates; Risa Kimmel; Kimberly E Applegate; Janice Granroth-Cook; Cheryl Denski; James Nguyen; Zhangsheng Yu; Eric Hoffman; Robert S Tepper
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Publication Detail:
Type:  Journal Article     Date:  2010-06-14
Journal Detail:
Title:  Academic radiology     Volume:  17     ISSN:  1878-4046     ISO Abbreviation:  Acad Radiol     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-08-09     Completed Date:  2011-01-10     Revised Date:  2014-09-12    
Medline Journal Info:
Nlm Unique ID:  9440159     Medline TA:  Acad Radiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1128-35     Citation Subset:  IM    
Copyright Information:
Copyright 2010 AUR. Published by Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Child
Child, Preschool
Female
Humans
Infant
Lung / growth & development*,  radiography*
Male
Models, Biological
Models, Statistical
Tidal Volume / physiology*
Tomography, X-Ray Computed / methods*
Grant Support
ID/Acronym/Agency:
R01 HL054062/HL/NHLBI NIH HHS; R01 HL054062-12/HL/NHLBI NIH HHS
Comments/Corrections

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