| Lung function and respiratory symptoms at 11 years in children born extremely preterm: the EPICure study. | |
| | |
MedLine Citation:
|
PMID: 20378729 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
RATIONALE: The long-term respiratory sequelae of infants born extremely preterm (EP) and now graduating from neonatal intensive care remains uncertain. OBJECTIVES: To assess the degree of respiratory morbidity and functional impairment at 11 years in children born EP (i.e., at or less than 25 completed weeks of gestation) in relation to neonatal determinants and current clinical status. METHODS: Pre- and postbronchodilator spirometry were undertaken at school in children born EP and classroom control subjects. Physical examination and respiratory health questionnaires were completed. Multivariable regression was used to estimate the predictive power of potential determinants of lung function. MEASUREMENTS AND MAIN RESULTS: Spirometry was obtained in 182 of 219 children born EP (129 with prior bronchopulmonary dysplasia [BPD]) and 161 of 169 classmates, matched for age, sex, and ethnic group. Children born EP had significantly more chest deformities and respiratory symptoms than classmates, with twice as many (25 vs. 13%; P < 0.01) having a current diagnosis of asthma. Baseline spirometry was significantly reduced (P < 0.001) and bronchodilator responsiveness was increased in those born EP, the changes being most marked in those with prior BPD. EP birth, BPD, current symptoms, and treatment with beta-agonists are each associated independently with lung function z-scores (adjusted for age, sex, and height) at 11 years. Fifty-six percent of children born EP had abnormal baseline spirometry and 27% had a positive bronchodilator response, but less than half of those with impaired lung function were receiving any medication. CONCLUSIONS: After extremely preterm birth, impaired lung function and increased respiratory morbidity persist into middle childhood, especially among those with BPD. Many of these children may not be receiving appropriate treatment. |
| | |
Authors:
|
Joseph Fawke; Sooky Lum; Jane Kirkby; Enid Hennessy; Neil Marlow; Victoria Rowell; Sue Thomas; Janet Stocks |
Related Documents
:
|
9141109 - Retrospective review of the effects of rhdnase in children with cystic fibrosis. 2817929 - Sudden death in asthma. 14679489 - Lower airway obstruction, bronchial hyperresponsiveness, and primary pulmonary hyperten... 1173819 - Hyperreactivity to cow milk in young children with pulmonary hemosiderosis and cor pulm... 1280129 - Regulation of lung endothelin content by the glucocorticosteroid budesonide. 8994399 - Relation of spirometric function to radiographic interstitial fibrosis in two large wor... 12699029 - Screening for disruptive behavior syndromes in children: the application of latent clas... 2600739 - Airway obstruction, palatal vault formation and malocclusion: a cross-sectional study. 16970809 - Risk factors for asthma and allergy associated with urban migration: background and met... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-04-08 |
Journal Detail:
|
Title: American journal of respiratory and critical care medicine Volume: 182 ISSN: 1535-4970 ISO Abbreviation: Am. J. Respir. Crit. Care Med. Publication Date: 2010 Jul |
Date Detail:
|
Created Date: 2010-07-16 Completed Date: 2010-09-14 Revised Date: 2011-07-20 |
Medline Journal Info:
|
Nlm Unique ID: 9421642 Medline TA: Am J Respir Crit Care Med Country: United States |
Other Details:
|
Languages: eng Pagination: 237-45 Citation Subset: AIM; IM |
Affiliation:
|
Portex Unit: Respiratory Physiology and Medicine, UCL, Institute of Child Health, WC1N 1EH London, UK. j.stocks@ich.ucl.ac.uk |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Asthma
/
epidemiology* Bronchial Hyperreactivity / diagnosis, epidemiology* Bronchodilator Agents / diagnostic use Bronchopulmonary Dysplasia / epidemiology Case-Control Studies Child Cohort Studies Follow-Up Studies Forced Expiratory Flow Rates Forced Expiratory Volume Funnel Chest / epidemiology* Humans Infant, Newborn Infant, Premature* Multivariate Analysis Respiratory Rate* Respiratory Sounds* Spirometry |
| Grant Support | |
ID/Acronym/Agency:
|
//Medical Research Council |
| Chemical | |
Reg. No./Substance:
|
0/Bronchodilator Agents |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Outcomes in Patients with Chronic Obstructive Pulmonary Disease and Obstructive Sleep Apnea. The Ove...
Next Document: Isoniazid-associated Hepatitis and Antiretroviral Drugs During Tuberculosis Prophylaxis in HIV-infec...