Document Detail


Lung B cells promote early pathogen dissemination and hasten death from inhalation anthrax.
MedLine Citation:
PMID:  22472773     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Sampling of mucosal antigens regulates immune responses but may also promote dissemination of mucosal pathogens. Lung dendritic cells (LDCs) capture antigens and traffic them to lung-draining lymph nodes (LDLNs) dependent on the chemokine receptor CCR7 (chemokine (C-C motif) receptor 7). LDCs also capture lung pathogens such as Bacillus anthracis (BA). However, we show here that the initial traffic of BA spores from lungs to LDLNs is largely independent of LDCs and CCR7, occurring instead in association with B cells. BA spores rapidly bound B cells in lungs and cultured mouse and human B cells. Binding was independent of the B-cell receptor (BCR). B cells instilled in the lungs trafficked to LDLNs and BA spore traffic to LDLNs was impaired by B-cell deficiency. Depletion of B cells also delayed death of mice receiving a lethal BA infection. These results suggest that mucosal B cells traffic BA, and possibly other antigens, from lungs to LDLNs.Mucosal Immunology advance online publication 4 April 2012; doi:10.1038/mi.2012.21.
Authors:
M Rayamajhi; C Delgado; T V Condon; D W Riches; L L Lenz
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-4-04
Journal Detail:
Title:  Mucosal immunology     Volume:  -     ISSN:  1935-3456     ISO Abbreviation:  -     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-4-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101299742     Medline TA:  Mucosal Immunol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
1] Integrated Department of Immunology, National Jewish Health, Denver, Colorado, USA [2] Integrated Department of Immunology, University of Colorado, Denver, Denver, Colorado, USA.
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