Document Detail

Lumped Parameter Model for Heart Failure with Novel Regulating Mechanisms of Peripheral Resistance and Vascular Compliance.
MedLine Citation:
PMID:  22395118     Owner:  NLM     Status:  Publisher    
To research the change in the physiological mechanism between the heart failure (HF) patient and healthy persons, the physiology parameters, which include the myocardial contractility, systemic vascular resistance (SVR), and vascular compliance, were studied. Through clinical data of HF patients, the computing method of the myocardial contractility was proposed; SVR as a function with respect to mean arterial pressure (MAP) was represented; and the vascular compliance was defined as a function with respect to MAP and cardiac output. Based on these parameters, a lumped parameter model of the cardiovascular system was established to reproduce the hemodynamic status of HF patients and verify the validity of the physiological mechanism. The simulation results demonstrate that the proportional error of mean flow, arterial pressure, and systolic blood pressure is 11.9%, 2.3%, and 4.7% compared with the clinical data, respectively. The proportional error of end-diastolic volume, end-systolic volume, and ejection fraction is 13.4%, 3%, and 3.9%, respectively.
Kaiyun Gu; Yu Chang; Bin Gao; Youjun Liu; Zhe Zhang; Feng Wan
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-3-4
Journal Detail:
Title:  ASAIO journal (American Society for Artificial Internal Organs : 1992)     Volume:  -     ISSN:  1538-943X     ISO Abbreviation:  -     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-3-7     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9204109     Medline TA:  ASAIO J     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
*School of Life Science and BioEngineering, Beijing University of Technology, Beijing, People's Republic of China †Peking University Third Hospital, Beijing, People's Republic of China.
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