| Luminescent amino-functionalized or erbium-doped silica spheres for biological applications. | |
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MedLine Citation:
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PMID: 18596357 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This work presents the morphological and optical properties of luminescent silica spheres, discussing applications in bioimaging and biosensing. The spheres are obtained by the hydrolysis and condensation of tetraethylorthosilicate (TEOS) and can be synthesized by following either a basic or an acidic route. Luminescence emission is induced after incorporation of aminopropyltriethoxysilane (APTES) during synthesis or by introducing an optically active element, such as erbium, or other rare-earth elements. The luminescence properties of APTES-functionalized silica spheres have been investigated and optimized by varying the annealing temperature. On the other hand, erbium incorporation in silica spheres was also studied and the corresponding Er(3+) luminescence emission at 1.54 microm was evaluated for intensity and lifetime. The basic pH environment in the synthesis allows good control of the size of the spheres (approximately 200 nm in diameter), whereas the acidic route produces a wide dispersion in particle size (200-5000 nm). Both these approaches, however, can be followed to obtain an efficient photoluminescence (PL) emission for the APTES-functionalized silica spheres after 400-600 degrees C thermal treatment. If Er(NO(3))(3) is introduced in the basic solution, a rapid precipitation of Er(OH)(3) occurs, but erbium can be easily and efficiently incorporated in the acid-synthesized spheres, showing high PL intensity at 1.54 microm with lifetime of 3.9 ms. Finally, I discuss perspectives for the applications of these luminescent silica spheres, in particular as biological markers for bioimaging and biosensing. |
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Authors:
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Francesco Enrichi |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Annals of the New York Academy of Sciences Volume: 1130 ISSN: 0077-8923 ISO Abbreviation: Ann. N. Y. Acad. Sci. Publication Date: 2008 |
Date Detail:
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Created Date: 2008-07-03 Completed Date: 2008-07-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7506858 Medline TA: Ann N Y Acad Sci Country: United States |
Other Details:
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Languages: eng Pagination: 262-6 Citation Subset: IM |
Affiliation:
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Associazione Coordinamento Interuniversitario Veneto per le Nanotecnologie, via delle Industrie 5, 30175 Marghera (Venice), Italy. enrichi@civen.org |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Biological Markers
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chemistry Erbium / chemistry* Hydrogen-Ion Concentration Luminescence* Microchemistry / methods* Microscopy, Electron, Scanning / methods Microspheres Organosilicon Compounds / chemistry Silanes / chemistry Silicon Dioxide / chemistry* Spectrophotometry / methods Spectroscopy, Fourier Transform Infrared / methods Temperature |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Organosilicon Compounds; 0/Silanes; 0/amino-propyl-triethoxysilane; 0/tetramethyl orthosilicate; 7440-52-0/Erbium; 7631-86-9/Silicon Dioxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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