| Luminescence and photophysical properties of benzo[a]phenothiazines--therapeutic, physico-chemical, and analytical applications. | |
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MedLine Citation:
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PMID: 17017887 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Luminescence studies on a series of new 12H-benzo[a]phenothiazines (BPHTs), possessing potentially useful antitumor therapeutic properties, are reviewed. The electronic absorption and fluorescence spectral properties of BPHTs, as well as their triplet- and singlet-excited states luminescence quenching are reviewed. Ground-state and singlet-excited state dipole moments and solvatochromic relationships are also described for these compounds. Studies on the formation of inclusion complexes between BPHTs and cyclodextrins (CDs), including CD-enhanced fluorescence, and thermodynamic constants and molecular geometry of these complexes, are discussed. The BPHTs antitumor properties in relation to their pi-electron density, and the physico-chemical and analytical applications based on their fluorescence and photophysical properties are also presented. This review article is based on selected literature data published in the last ten years (1993-2004). |
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Authors:
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Mame Diabou Gaye-Seye; Jean-Jacques Aaron; Cyril Párkányi; Noboru Motohashi |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Current drug targets Volume: 7 ISSN: 1873-5592 ISO Abbreviation: Curr Drug Targets Publication Date: 2006 Sep |
Date Detail:
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Created Date: 2006-10-04 Completed Date: 2006-11-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100960531 Medline TA: Curr Drug Targets Country: Netherlands |
Other Details:
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Languages: eng Pagination: 1083-93 Citation Subset: IM |
Affiliation:
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ITODYS, Université Paris 7--Denis-Diderot, Associé au CNRS UMR 70-86, 1, rue Guy de la Brosse, 75005 Paris, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antineoplastic Agents / analysis, chemistry, therapeutic use Chemistry, Physical / trends Humans Luminescent Agents / analysis, chemistry*, therapeutic use* Phenothiazines / analysis, chemistry*, therapeutic use* Photochemistry / trends Spectrometry, Fluorescence / trends |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 0/Luminescent Agents; 0/Phenothiazines; 28453-74-9/benzophenothiazine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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