| Luminance-dependent decrease in vasoactive intestinal polypeptide in the rat suprachiasmatic nucleus. | |
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MedLine Citation:
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PMID: 9714455 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Light responsiveness of the vasoactive intestinal polypeptide (VIP) content in the suprachiasmatic nucleus (SCN) of the rat with pupils dilated by atropine was examined by enzyme immunoassay. After exposure to 6 h light at 3-1000 lux VIP levels in the SCN decreased as a monotonic function with a working range from 3 to 300 lux. At 12 h, 30 lux light decreased the VIP content to the minimum level that was attained by 300 lux light exposure in 6 h, suggesting that brighter illumination decreases VIP levels more rapidly, but light at a luminance of 0.05 lux for 3 days did not suppress VIP levels. These results suggest that VIP in the SCN codes visual information on luminance with a small working range and a relative high threshold. |
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Authors:
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K Shinohara; K Tominaga; S T Inouye |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Neuroscience letters Volume: 251 ISSN: 0304-3940 ISO Abbreviation: Neurosci. Lett. Publication Date: 1998 Jul |
Date Detail:
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Created Date: 1998-11-02 Completed Date: 1998-11-02 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7600130 Medline TA: Neurosci Lett Country: IRELAND |
Other Details:
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Languages: eng Pagination: 21-4 Citation Subset: IM |
Affiliation:
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Department of Physiology, Yokohama City University School of Medicine, Japan. kazuyuki@med.yokohama-cu.ac.jp |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Atropine Dose-Response Relationship, Radiation Light* Lighting Male Pupil Rats Rats, Wistar Suprachiasmatic Nucleus / metabolism, radiation effects* Time Factors Vasoactive Intestinal Peptide / metabolism* |
| Chemical | |
Reg. No./Substance:
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37221-79-7/Vasoactive Intestinal Peptide; 51-55-8/Atropine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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