| Luminal peroxides in intestinal thiol-disulfide balance and cell turnover. | |
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MedLine Citation:
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PMID: 9467860 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Dietary intake of highly polyunsaturated fats represents a major source of lipid hydroperoxides in the intestinal lumen. Under conditions of high peroxide intake, excessive concentrations of lipid hydroperoxides can persist in the gut lumen and contribute to impairment of mucosal GSH-dependent detoxication pathways, enterocyte dysfunction independent of cell injury, and development of gut pathologies, including cancer. This paper summarizes our current knowledge of the determinants of intestinal lipid hydroperoxide metabolism and of the physiological and biochemical processes in lipid peroxide-mediated changes in intestinal redox status, regulation of mucosal thiol and antioxidant balance and control of intestinal cell turnover. This discussion is pertinent to understanding dietary peroxides and thiol redox balance in intestinal physiology and pathophysiology and the potential benefit of oral GSH in preserving metabolic integrity of the intestinal epithelium. |
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Authors:
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T Y Aw |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology Volume: 118 ISSN: 1096-4959 ISO Abbreviation: Comp. Biochem. Physiol. B, Biochem. Mol. Biol. Publication Date: 1997 Nov |
Date Detail:
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Created Date: 1998-03-11 Completed Date: 1998-03-11 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9516061 Medline TA: Comp Biochem Physiol B Biochem Mol Biol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 479-85 Citation Subset: IM |
Affiliation:
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Department of Molecular and Cellular Physiology, LSU Medical Center, Shreveport, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Disulfides / metabolism* Glutathione / metabolism, pharmacology Humans Hydrogen Peroxide / metabolism Intestines / cytology*, metabolism* Lipid Metabolism NADP / metabolism Oxidation-Reduction Peroxides / metabolism* Sulfhydryl Compounds / metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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DK-44510/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Disulfides; 0/Peroxides; 0/Sulfhydryl Compounds; 53-59-8/NADP; 70-18-8/Glutathione; 7722-84-1/Hydrogen Peroxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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