| Luminal flow patterns dictate arterial drug deposition in stent-based delivery. | |
| | |
MedLine Citation:
|
PMID: 18926864 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Endovascular stents reside in a dynamic flow environment and yet the impact of flow on arterial drug deposition after stent-based delivery is only now emerging. We employed computational fluid dynamic modeling tools to investigate the influence of luminal flow patterns on arterial drug deposition and distribution. Flow imposes recirculation zones distal and proximal to the stent strut that extend the coverage of tissue absorption of eluted drug and induce asymmetry in tissue drug distribution. Our analysis now explains how the disparity in sizes of the two recirculation zones and the asymmetry in drug distribution are determined by a complex interplay of local flow and strut geometry. When temporal periodicity was introduced as a model of pulsatile flow, the net luminal flow served as an index of flow-mediated spatio-temporal tissue drug uptake. Dynamically changing luminal flow patterns are intrinsic to the coronary arterial tree. Coronary drug-eluting stents should be appropriately considered where luminal flow, strut design and pulsatility have direct effects on tissue drug uptake after local delivery. |
| | |
Authors:
|
Vijaya B Kolachalama; Abraham R Tzafriri; Davis Y Arifin; Elazer R Edelman |
Related Documents
:
|
8149544 - Liposome-bound prostaglandin e1 often prevents cyclic flow variations in stenosed and e... 3973264 - Relation of coronary blood flow and reactive hyperemia to regional dysfunction induced ... 8594934 - Effects of estrogen in vivo on coronary vascular resistance in perfused rabbit hearts. 11675634 - 3d coronary vessel wall imaging utilizing a local inversion technique with spiral image... 717874 - A technique for pinealectomy in deer, with notes on the neuroanatomy. 9040544 - Use of thyroid stimulating hormone testing in newborns to identify iodine deficiency. |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural Date: 2008-09-26 |
Journal Detail:
|
Title: Journal of controlled release : official journal of the Controlled Release Society Volume: 133 ISSN: 1873-4995 ISO Abbreviation: J Control Release Publication Date: 2009 Jan |
Date Detail:
|
Created Date: 2008-12-08 Completed Date: 2009-02-17 Revised Date: 2010-12-03 |
Medline Journal Info:
|
Nlm Unique ID: 8607908 Medline TA: J Control Release Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 24-30 Citation Subset: IM |
Affiliation:
|
Biomedical Engineering Center, Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, USA. vbk@mit.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Algorithms Area Under Curve Arteries / metabolism, physiology Blood Flow Velocity / physiology Blood Viscosity / physiology Computer Simulation Coronary Restenosis / drug therapy Diffusion Drug Delivery Systems / methods Drug-Eluting Stents* Hemorheology / physiology Humans Models, Biological* Pharmaceutical Preparations / administration & dosage, metabolism* Pharmacokinetics* Pulsatile Flow / physiology |
| Grant Support | |
ID/Acronym/Agency:
|
R01 GM049039-13A1/GM/NIGMS NIH HHS; R01 GM049039-16/GM/NIGMS NIH HHS; R01 HL49039/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Pharmaceutical Preparations |
| Comments/Corrections | |
Comment In:
|
J Control Release. 2009 Jan 5;133(1):1
[PMID:
19038297
]
|
Erratum In:
|
J Control Release. 2010 Aug 17;146(1):160 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Action monitoring and depressive symptom reduction in major depressive disorder.
Next Document: Appetite regulation via exercise prior or subsequent to high-fat meal consumption.