Document Detail

Luminal capsaicin inhibits fluid secretion induced by enterotoxin E. coli STa, but not by carbachol, in vivo in rat small and large intestine.
MedLine Citation:
PMID:  8845145     Owner:  NLM     Status:  MEDLINE    
The enterotoxin E. coli STa induced fluid secretion in the rat jejunum, ileum and proximal colon in vivo that was greatly inhibited by the co-presence of luminal capsaicin, which is a specific neural toxin of afferent C fibres. The same dose of capsaicin had no effect on the fluid secretion activated by carbachol in the jejunum, ileum and proximal colon. Afferent C fibres appear to be involved in the activation by STa of fluid secretion in the rat intestine in vivo.
H C Nzegwu; R J Levin
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Experimental physiology     Volume:  81     ISSN:  0958-0670     ISO Abbreviation:  Exp. Physiol.     Publication Date:  1996 Mar 
Date Detail:
Created Date:  1996-10-24     Completed Date:  1996-10-24     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  9002940     Medline TA:  Exp Physiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  313-5     Citation Subset:  IM    
Faculty of Health and Social Work, Anglia Polytechnic University, Chelmsford, UK.
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MeSH Terms
Afferent Pathways / physiology
Capsaicin / pharmacology*
Carbachol / pharmacology*
Chlorides / metabolism
Enterotoxins / antagonists & inhibitors,  pharmacology
Escherichia coli
Intestinal Secretions / drug effects*,  physiology
Nerve Fibers / drug effects,  metabolism
Neurotoxins / pharmacology
Rats, Inbred Strains
Reg. No./Substance:
0/Chlorides; 0/Enterotoxins; 0/Neurotoxins; 404-86-4/Capsaicin; 51-83-2/Carbachol

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