Document Detail

Lumen narrowing after percutaneous transluminal coronary balloon angioplasty follows a near gaussian distribution: a quantitative angiographic study in 1,445 successfully dilated lesions.
MedLine Citation:
PMID:  1552115     Owner:  NLM     Status:  MEDLINE    
To determine whether significant angiographic narrowing and restenosis after successful coronary balloon angioplasty is a specific disease entity occurring in a subset of dilated lesions or whether it is the tail end of a gaussian distributed phenomenon, 1,445 successfully dilated lesions were studied before and after coronary angioplasty and at 6-month follow-up study. The original cohort consisted of 1,353 patients of whom 1,232 underwent repeat angiography with quantitative analysis (follow-up rate 91.2%). Quantitative angiography was carried out off-line in a central core laboratory with an automated edge detection technique. Analyses were performed by analysts not involved with patient care. Distributions of minimal lumen diameter before angioplasty (1.03 +/- 0.37 mm), after angioplasty (1.78 +/- 0.36 mm) and at 6-month follow-up study (1.50 +/- 0.57 mm) as well as the percent diameter stenosis at 6-month follow-up study (44 +/- 19%) were assessed. The change in minimal lumen diameter from the post-angioplasty angiogram to the follow-up angiogram was also determined (-0.28 +/- 0.52 mm). Seventy lesions progressed toward total occlusion at follow-up. All observed distributions approximately followed a normal or gaussian distribution. Therefore, restenosis can be viewed as the tail end of an approximately gaussian distributed phenomenon, with some lesions crossing a more or less arbitrary cutoff point, rather than as a separate disease entity occurring in some lesions but not in others.
B J Rensing; W R Hermans; J W Deckers; P J de Feyter; J G Tijssen; P W Serruys
Related Documents :
22915935 - Everolimus-eluting stents: update on current clinical studies.
12668835 - Brachytherapy for refractory coronary artery restenosis.
14556865 - Evaluation of the association of proximal coronary culprit artery lesion location with ...
21499085 - Downregulation of adiponectin induced by tumor necrosis factor α is involved in the ag...
11105025 - Investigating intrinsic myocardial mechanics: the role of mr tagging, velocity phase ma...
14704225 - Heterogeneous connexin43 expression produces electrophysiological heterogeneities acros...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of the American College of Cardiology     Volume:  19     ISSN:  0735-1097     ISO Abbreviation:  J. Am. Coll. Cardiol.     Publication Date:  1992 Apr 
Date Detail:
Created Date:  1992-04-30     Completed Date:  1992-04-30     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8301365     Medline TA:  J Am Coll Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  939-45     Citation Subset:  AIM; IM    
Thoraxcenter, Erasmus University, Rotterdam, The Netherlands.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Angioplasty, Transluminal, Percutaneous Coronary*
Cohort Studies
Constriction, Pathologic / epidemiology,  pathology,  radiography
Coronary Angiography
Coronary Artery Disease / epidemiology*,  pathology,  radiography
Coronary Vessels / pathology
Middle Aged
Normal Distribution
Time Factors
Comment In:
J Am Coll Cardiol. 1992 Apr;19(5):946-7   [PMID:  1552116 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Abrupt vessel closure complicating coronary angioplasty: clinical, angiographic and therapeutic prof...
Next Document:  Assessment of residual tissue viability by exercise testing in recent myocardial infarction: compari...