| Lumen irregularity dominates the relationship between mechanical stress condition, fibrous-cap thickness, and lumen curvature in carotid atherosclerotic plaque. | |
| | |
MedLine Citation:
|
PMID: 21303186 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
High mechanical stress condition over the fibrous cap (FC) has been widely accepted as a contributor to plaque rupture. The relationships between the stress, lumen curvature, and FC thickness have not been explored in detail. In this study, we investigate lumen irregularity-dependent relationships between mechanical stress conditions, local FC thickness (LT(FC)), and lumen curvature (LC(lumen)). Magnetic resonance imaging slices of carotid plaque from 100 patients with delineated atherosclerotic components were used. Two-dimensional structure-only finite element simulations were performed for the mechanical analysis, and maximum principal stress (stress-P(1)) at all integral nodes along the lumen was obtained. LT(FC) and LC(lumen) were computed using the segmented contour. The lumen irregularity (L-δir) was defined as the difference between the largest and the smallest lumen curvature. The results indicated that the relationship between stress-P(1), LT(FC), and LC(lumen) is largely dependent on L-δir. When L-δir≥1.31 (irregular lumen), stress-P(1) strongly correlated with lumen curvature and had a weak/no correlation with local FC thickness, and in 73.4% of magnetic resonance (MR) slices, the critical stress (maximum of stress-P(1) over the diseased region) was found at the site where the lumen curvature was large. When L-δir≤0.28 (relatively round lumen), stress-P(1) showed a strong correlation with local FC thickness but weak/no correlation with lumen curvature, and in 71.7% of MR slices, the critical stress was located at the site of minimum FC thickness. Using lumen irregularity as a method of identifying vulnerable plaque sites by referring to the lumen shape is a novel and simple method, which can be used for mechanics-based plaque vulnerability assessment. |
| | |
Authors:
|
Zhongzhao Teng; Umar Sadat; Guangyu Ji; Chengcheng Zhu; Victoria E Young; Martin J Graves; Jonathan H Gillard |
Related Documents
:
|
20868846 - Intrapulmonary cellular schwannoma. 21331926 - Fdg pet imaging of head and neck cancers. 1961936 - Primary intracardiac tumors in magnetic resonance imaging. 20585926 - Malignant transformation of a mature cystic teratoma of the ovary with rupture. 2805536 - Bone imaging in patients with unexpected elevation of serum alkaline phosphatase. 20378466 - A registration-based propagation framework for automatic whole heart segmentation of ca... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Journal of biomechanical engineering Volume: 133 ISSN: 1528-8951 ISO Abbreviation: J Biomech Eng Publication Date: 2011 Mar |
Date Detail:
|
Created Date: 2011-02-09 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7909584 Medline TA: J Biomech Eng Country: United States |
Other Details:
|
Languages: eng Pagination: 034501 Citation Subset: IM |
Affiliation:
|
Department of Radiology, University of Cambridge, Cambridge, CB2 0QQ, UK. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Nonlinear smooth orthogonal decomposition of kinematic features of sawing reconstructs muscle fatigu...
Next Document: Complementary limb motion estimation for the control of active knee prostheses.