Document Detail


Lumbar spinal canal stenosis examined electrophysiologically in a rat model of chronic cauda equina compression.
MedLine Citation:
PMID:  9399449     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
STUDY DESIGN: A model of chronic cauda equina compression with conductive stress was studied electrophysiologically. OBJECTIVE: To analyze the pathophysiology arising from chronic compression electrophysiologically. SUMMARY OF BACKGROUND DATA: This rat model of cauda equina compression that is chronic, not acute, has been reported elsewhere. METHODS: A stainless steel wire and plate were fastened to the spine at L5 of 8 rats 3 weeks old. One year later, the ascending and descending nerve action potentials were recorded and the conduction velocities (CVs) were measured. Electrophysiologic changes after high-frequency stimulation (HFS) were observed. RESULTS: The waveform of the ascending cauda equina action potential at the cauda equina had three peaks, and that at the conus medullaris had a peak followed by a broad wave. The waveform of the descending nerve action potential had two peaks. The mean ascending and descending CVs of the treated rats were slower (P < 0.001) than those of the control rats. In the control rats, the mean CV and mean amplitude after HFS decreased slightly and returned to normal within 30 seconds, and the waveform was unchanged. In treated rats, the mean CV decreased after HFS but returned to normal within 10 minutes. The mean amplitude decreased after HFS and did not return to normal within 10 minutes. The waveform was unchanged. CONCLUSIONS: Because the differences between treated and control rats in amplitude (and CVs) were greater before HFS than after HFS, we concluded that treated rats had disturbance of the blood flow in vessels around the nerves of the cauda equina with histologic damage. In human patients, such disturbance may be one cause of intermittent claudication.
Authors:
H Iwamoto; H Matsuda; A Noriage; Y Yamano
Related Documents :
9406949 - Reversible sedimentation and masking of nerve growth factor (ngf) antigen by high molec...
21670219 - Disposition and metabolism of ticagrelor, a novel p2y12 receptor antagonist, in mice, r...
17513489 - High oxygen tension constricts epineurial arterioles of the rat sciatic nerve via react...
12196709 - A selective loss of small-diameter myelinated optic nerve axons in rats prenatally expo...
6501609 - The postnatal development of the tract of lissauer in the rat.
11182479 - Responsiveness of sympathetic and sensory iridial nerves to ngf treatment in young and ...
10416279 - Toxic characteristics of the synthetic lipid a derivative dt-5461 in rats and monkeys.
17460359 - Changes of estrous cycles with aging in female f344/n rats.
15455119 - Metabolic correction of gas exchange disturbances in rats with barbiturate coma.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Spine     Volume:  22     ISSN:  0362-2436     ISO Abbreviation:  Spine     Publication Date:  1997 Nov 
Date Detail:
Created Date:  1998-01-02     Completed Date:  1998-01-02     Revised Date:  2009-07-09    
Medline Journal Info:
Nlm Unique ID:  7610646     Medline TA:  Spine (Phila Pa 1976)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2636-40     Citation Subset:  IM    
Affiliation:
Department of Orthopaedic Surgery, Osaka City University Medical School, Osaka, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Action Potentials / physiology
Animals
Cauda Equina / physiopathology*
Chronic Disease
Disease Models, Animal
Electrophysiology
Lumbar Vertebrae
Male
Nerve Compression Syndromes / etiology,  physiopathology*
Neural Conduction
Rats
Rats, Sprague-Dawley
Spinal Stenosis / complications,  physiopathology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Characterization of the scoliosis that develops after pinealectomy in the chicken and comparison wit...
Next Document:  Pathogenesis of tears of the anulus investigated by multiple-level transaxial analysis of the T12-L1...