Document Detail

Lumbar nerve root compression due to extramedullary hemopoiesis in a patient with thalassemia: complete clinical regression with radiation therapy. Case report and review of the literature.
MedLine Citation:
PMID:  17330584     Owner:  NLM     Status:  MEDLINE    
The authors describe the case of a 24-year-old woman who had a history of beta3-thalassemia and presented with severe symptoms of lumbar nerve root compression due to extramedullary hemopoiesis in the intervertebral foramen. Radiation therapy (2000 cGy in six fractions) was delivered to the mass. The patient's neurological symptoms completely resolved following treatment. Follow-up images showed a reduction in lesion size. The results of this unique case supported by a review of the literature suggest that radiation therapy alone is an effective modality in the treatment of patients with compression of neural structures due to extramedullary hemopoietic tissue.
Philippos Tsitsopoulos; Dimitris Zevgaridis; Parmenion Tsitsopoulos; Christos Tsonidis; Ioannis Anagnostopoulos; Dimitris Marinopoulos
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of neurosurgery. Spine     Volume:  6     ISSN:  1547-5654     ISO Abbreviation:  -     Publication Date:  2007 Feb 
Date Detail:
Created Date:  2007-03-02     Completed Date:  2007-03-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101223545     Medline TA:  J Neurosurg Spine     Country:  United States    
Other Details:
Languages:  eng     Pagination:  156-60     Citation Subset:  IM    
Department of Neurosurgery, Medical School of Aristotle University, Hippokration Hospital, Thessaloniki, Greece.
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MeSH Terms
Dose-Response Relationship, Radiation
Hematopoiesis, Extramedullary* / radiation effects
Lumbosacral Region
Magnetic Resonance Imaging
Nerve Compression Syndromes / diagnosis,  etiology*
Spinal Nerve Roots*
Thalassemia / complications*,  physiopathology*,  radiotherapy
Tomography, X-Ray Computed
Treatment Outcome

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