Document Detail

Lucidenic acid O and lactone, new terpene inhibitors of eukaryotic DNA polymerases from a basidiomycete, Ganoderma lucidum.
MedLine Citation:
PMID:  10530954     Owner:  NLM     Status:  MEDLINE    
Terpenoids, 1, 2 and 3, which selectively inhibit eukaryotic DNA polymerase activities, were isolated from the fruiting body of a basidiomycete, Ganoderma lucidum, and their structures were determined by spectroscopic analyses. New terpenes, lucidenic acid O (1) and lucidenic lactone (2), prevented not only the activities of calf DNA polymerase alpha and rat DNA polymerase beta, but also these of human immunodeficiency virus type 1 reverse transcriptase. Cerevisterol (3), which was reported to be a cytotoxic steroid, inhibited only the activity of DNA polymerase alpha. Although these compounds did not influence the activities of prokaryotic DNA polymerases and other DNA metabolic enzymes such as T7 RNA polymerase and deoxyribonuclease I.
Y Mizushina; N Takahashi; L Hanashima; H Koshino; Y Esumi; J Uzawa; F Sugawara; K Sakaguchi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Bioorganic & medicinal chemistry     Volume:  7     ISSN:  0968-0896     ISO Abbreviation:  Bioorg. Med. Chem.     Publication Date:  1999 Sep 
Date Detail:
Created Date:  1999-11-18     Completed Date:  1999-11-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9413298     Medline TA:  Bioorg Med Chem     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  2047-52     Citation Subset:  IM; X    
Department of Applied Biological Science, Science University of Tokyo, Chiba, Japan.
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MeSH Terms
Basidiomycota / chemistry*
DNA-Directed DNA Polymerase / antagonists & inhibitors*
Enzyme Inhibitors / isolation & purification,  pharmacology*
Molecular Structure
Spectrum Analysis
Terpenes / chemistry,  isolation & purification,  pharmacology*
Reg. No./Substance:
0/Enzyme Inhibitors; 0/Terpenes; 0/lucidenic acid O; 0/lucidenic lactone; EC DNA Polymerase

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