| Lucidenic acid O and lactone, new terpene inhibitors of eukaryotic DNA polymerases from a basidiomycete, Ganoderma lucidum. | |
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MedLine Citation:
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PMID: 10530954 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Terpenoids, 1, 2 and 3, which selectively inhibit eukaryotic DNA polymerase activities, were isolated from the fruiting body of a basidiomycete, Ganoderma lucidum, and their structures were determined by spectroscopic analyses. New terpenes, lucidenic acid O (1) and lucidenic lactone (2), prevented not only the activities of calf DNA polymerase alpha and rat DNA polymerase beta, but also these of human immunodeficiency virus type 1 reverse transcriptase. Cerevisterol (3), which was reported to be a cytotoxic steroid, inhibited only the activity of DNA polymerase alpha. Although these compounds did not influence the activities of prokaryotic DNA polymerases and other DNA metabolic enzymes such as T7 RNA polymerase and deoxyribonuclease I. |
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Authors:
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Y Mizushina; N Takahashi; L Hanashima; H Koshino; Y Esumi; J Uzawa; F Sugawara; K Sakaguchi |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Bioorganic & medicinal chemistry Volume: 7 ISSN: 0968-0896 ISO Abbreviation: Bioorg. Med. Chem. Publication Date: 1999 Sep |
Date Detail:
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Created Date: 1999-11-18 Completed Date: 1999-11-18 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9413298 Medline TA: Bioorg Med Chem Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 2047-52 Citation Subset: IM; X |
Affiliation:
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Department of Applied Biological Science, Science University of Tokyo, Chiba, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Basidiomycota / chemistry* Cattle DNA-Directed DNA Polymerase / antagonists & inhibitors* Enzyme Inhibitors / isolation & purification, pharmacology* Humans Molecular Structure Rats Spectrum Analysis Terpenes / chemistry, isolation & purification, pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Enzyme Inhibitors; 0/Terpenes; 0/lucidenic acid O; 0/lucidenic lactone; EC 2.7.7.7/DNA-Directed DNA Polymerase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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