| Lubrication properties of potential alternative lubricants, glycerin fatty acid esters, to magnesium stearate. | |
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MedLine Citation:
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PMID: 19913080 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To study the usefulness of glycerin fatty acid ester Poem TR-FB (TR-FB) and Poem TR-HB (TR-HB) as lubricants, pressure transmission ratio, ejection force, disintegration time, and tensile strength were measured at different concentrations and mixing times for granules and tablets. When each lubricant was mixed at 0.1-3.0%, the increase in the pressure transmission ratio that was equal to or greater than that of Mg-St as well as the reduction in the ejection force was observed at a low concentration in both TR-FB and TR-HB, proving that they have excellent lubrication performance. The granules that were lubricated with TR-FB and TR-HB at even low concentration of 0.4% showed a more stable and sufficiently lower ejection force than with Mg-St from the first tablet after the start of compression. When they were mixed for 5-60 min, while the mixture with Mg-St showed a low pressure transmission ratio of 82% and a high ejection force of 500 N in the first tablet even when the mixing time was 60 min, a high pressure transmission ratio and a low ejection force were observed in TR-FB and TR-HB from the first tablet after mixing for 5-60 min, and these were maintained thereafter. As for the disintegration time and the tensile strength, a prolonged disintegration time and a decreased tensile strength, which are disadvantages of Mg-St, were not observed in TR-FB and TR-HB. Based on these results, it was concluded that TR-FB and TR-HB are useful as alternative lubricants to Mg-St. |
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Authors:
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Takeaki Uchimoto; Yasunori Iwao; Yuki Ikegami; Takashi Murata; Takashi Sonobe; Atsuo Miyagishima; Shigeru Itai |
Publication Detail:
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Type: Journal Article Date: 2009-11-11 |
Journal Detail:
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Title: International journal of pharmaceutics Volume: 386 ISSN: 1873-3476 ISO Abbreviation: Int J Pharm Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-02-01 Completed Date: 2010-04-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7804127 Medline TA: Int J Pharm Country: Netherlands |
Other Details:
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Languages: eng Pagination: 91-8 Citation Subset: IM |
Copyright Information:
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Copyright 2009 Elsevier B.V. All rights reserved. |
Affiliation:
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Department of Pharmaceutical Engineering, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Chemistry, Pharmaceutical Fatty Acids / chemistry* Glycerol / analogs & derivatives, chemistry* Hardness Kinetics Lubricants / chemistry* Models, Chemical Pressure Solubility Stearic Acids / chemistry* Tablets Technology, Pharmaceutical / methods Tensile Strength |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids; 0/Lubricants; 0/Stearic Acids; 0/Tablets; 56-81-5/Glycerol; 57-11-4/stearic acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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