Document Detail


Lp-PLA₂- a novel risk factor for high-risk coronary and carotid artery disease.
MedLine Citation:
PMID:  21054587     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Lipoprotein-associated phospholipase A2 (Lp-PLA₂) is at the crossroads of lipid metabolism and the inflammatory response. It is produced by inflammatory cells, bound to LDL and other lipoproteins, and once in the arterial wall facilitates hydrolysis of phospholipids. Elevated serum levels of Lp-PLA₂ have been associated with increased cardiovascular risk in healthy populations and in patients with known vascular disease. Here, we review the role of Lp-PLA₂ in the development of atherosclerosis and progression to unstable disease, the utility of Lp-PLA₂ as a risk predictor for coronary and carotid events and the potential clinical benefit of pharmacologic inhibition of Lp-PLA₂.
Authors:
K C Epps; R L Wilensky
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Publication Detail:
Type:  Journal Article; Review     Date:  2010-11-05
Journal Detail:
Title:  Journal of internal medicine     Volume:  269     ISSN:  1365-2796     ISO Abbreviation:  J. Intern. Med.     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2010-12-16     Completed Date:  2011-01-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8904841     Medline TA:  J Intern Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  94-106     Citation Subset:  IM    
Copyright Information:
© 2010 The Association for the Publication of the Journal of Internal Medicine.
Affiliation:
Cardiovascular Division, Hospital of the University of Pennsylvania and Cardiovascular Institute, University of Pennsylvania, Philadelphia, PA, USA.
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MeSH Terms
Descriptor/Qualifier:
1-Alkyl-2-acetylglycerophosphocholine Esterase / antagonists & inhibitors,  blood*,  physiology
Biological Markers / blood
Carotid Artery Diseases / enzymology*
Clinical Trials, Phase III as Topic
Coronary Disease / enzymology*
Female
Humans
Male
Risk Factors
Stroke / enzymology
Structure-Activity Relationship
Chemical
Reg. No./Substance:
0/Biological Markers; EC 3.1.1.47/1-Alkyl-2-acetylglycerophosphocholine Esterase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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