| Loxoprofen sodium treatment for elderly men with refractory nocturia: effect on night-time urine production. | |
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MedLine Citation:
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PMID: 18452468 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We evaluated the efficacy of loxoprofen sodium for refractory nocturia. Twelve men (mean age, 75.1 +/- 5.7) with nocturia were enrolled in this study. All patients received 60 mg loxoprofen sodium prior to sleeping at night for 14 days. Nine of 12 patients (75%) felt more satisfaction than previous treatments. Patients were grouped into a loxoprofen sodium-effective (n = 7) and ineffective groups (n = 5) based on the results of the frequency-volume chart. In the effective group, interestingly, night-time urine volume showed significant reduction (P < 0.05). On the other hand, the average single voided volume at night and 24-h urine volume showed no significant change. There was a statistically significant difference in the night-time urine volume after treatment between groups (P < 0.01). Loxoprofen sodium is an effective treatment for some patients with refractory nocturia. The main effect mechanism of loxoprofen sodium may involve the reduction of night-time urine production. |
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Authors:
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Shinsuke Okada; Hideki Watanabe; Yoshiyuki Kojima; Yoshimasa Yanai; Shoichi Sasaki; Kenjiro Kohri |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: International journal of urology : official journal of the Japanese Urological Association Volume: 15 ISSN: 1442-2042 ISO Abbreviation: Int. J. Urol. Publication Date: 2008 May |
Date Detail:
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Created Date: 2008-05-02 Completed Date: 2008-09-15 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9440237 Medline TA: Int J Urol Country: Australia |
Other Details:
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Languages: eng Pagination: 462-4 Citation Subset: IM |
Affiliation:
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Department of Nephro-urology, Nagoya City University Graduate School of Medical Sciences, and Department of Urology, Jousai Municipal Hospital, Nagoya, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Anti-Inflammatory Agents, Non-Steroidal / therapeutic use* Humans Male Nocturia / drug therapy* Phenylpropionates / therapeutic use* Urine |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents, Non-Steroidal; 0/Phenylpropionates; 68767-14-6/loxoprofen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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