Document Detail

Loxoprofen sodium treatment for elderly men with refractory nocturia: effect on night-time urine production.
MedLine Citation:
PMID:  18452468     Owner:  NLM     Status:  MEDLINE    
We evaluated the efficacy of loxoprofen sodium for refractory nocturia. Twelve men (mean age, 75.1 +/- 5.7) with nocturia were enrolled in this study. All patients received 60 mg loxoprofen sodium prior to sleeping at night for 14 days. Nine of 12 patients (75%) felt more satisfaction than previous treatments. Patients were grouped into a loxoprofen sodium-effective (n = 7) and ineffective groups (n = 5) based on the results of the frequency-volume chart. In the effective group, interestingly, night-time urine volume showed significant reduction (P < 0.05). On the other hand, the average single voided volume at night and 24-h urine volume showed no significant change. There was a statistically significant difference in the night-time urine volume after treatment between groups (P < 0.01). Loxoprofen sodium is an effective treatment for some patients with refractory nocturia. The main effect mechanism of loxoprofen sodium may involve the reduction of night-time urine production.
Shinsuke Okada; Hideki Watanabe; Yoshiyuki Kojima; Yoshimasa Yanai; Shoichi Sasaki; Kenjiro Kohri
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of urology : official journal of the Japanese Urological Association     Volume:  15     ISSN:  1442-2042     ISO Abbreviation:  Int. J. Urol.     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-05-02     Completed Date:  2008-09-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9440237     Medline TA:  Int J Urol     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  462-4     Citation Subset:  IM    
Department of Nephro-urology, Nagoya City University Graduate School of Medical Sciences, and Department of Urology, Jousai Municipal Hospital, Nagoya, Japan.
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MeSH Terms
Aged, 80 and over
Anti-Inflammatory Agents, Non-Steroidal / therapeutic use*
Nocturia / drug therapy*
Phenylpropionates / therapeutic use*
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 0/Phenylpropionates; 68767-14-6/loxoprofen

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