|Lowering the dose of sirolimus, released from a nonpolymeric hydroxyapatite coated coronary stent, reduces signs of delayed healing.|
|PMID: 19463438 Owner: NLM Status: MEDLINE|
|OBJECTIVES: The aim of this study was to compare efficacy of low- and high-dose sirolimus release (25, 40, or 100 microg) from hydroxyapatite (HAp) with Cypher (Cordis, Johnson & Johnson, Warren, New Jersey) (111 microg sirolimus) in porcine coronary arteries.
BACKGROUND: Polymer-based sirolimus-eluting stents such as Cypher interfere with vascular healing, probably due to the permanent presence of the polymer coating and the high sirolimus dose. The use of low-dose sirolimus and inert nonpolymeric but biodegradable coatings such as HAp might be more appropriate.
METHODS: Stents (n = 68) were implanted, guided by quantitative coronary angiography. All swine received clopidogrel and acetylsalicylic acid during 28 days follow-up. Safety of the coating in absence of drugs was studied by comparing HAp with and without a lipid-based release regulating layer (HApR) with bare-metal stents. Efficacy was studied by comparing the release of 25, 40, and 100 microg sirolimus with Cypher.
RESULTS: The safety study (without drug) revealed no differences in neointimal thickening in response to HAp and HApR with complete healing in all groups. Dose response analysis showed that neointimal thickening was similar in all groups regardless of sirolimus dose, with a normal appearance of the endothelium. There was, however, a dose-dependent increase in fibrinoid (p = 0.028), considered to be a marker of delayed healing. The Cypher stent induced the highest amount of fibrinoid.
CONCLUSIONS: Reducing the dose of sirolimus eluting from a biocompatible HAp coated stent reduces signs of delayed vascular healing, without affecting neointimal hyperplasia.
|Wim J van der Giessen; Oana Sorop; Patrick W Serruys; Ilona Peters-Krabbendam; Heleen M M van Beusekom|
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|Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't|
|Title: JACC. Cardiovascular interventions Volume: 2 ISSN: 1876-7605 ISO Abbreviation: JACC Cardiovasc Interv Publication Date: 2009 Apr|
|Created Date: 2009-05-25 Completed Date: 2009-08-03 Revised Date: 2014-09-05|
Medline Journal Info:
|Nlm Unique ID: 101467004 Medline TA: JACC Cardiovasc Interv Country: United States|
|Languages: eng Pagination: 284-90 Citation Subset: IM|
|APA/MLA Format Download EndNote Download BibTex|
Angioplasty, Balloon, Coronary
Aspirin / administration & dosage
Cardiovascular Agents / administration & dosage*
Coated Materials, Biocompatible*
Coronary Restenosis / etiology, prevention & control
Coronary Vessels / drug effects*, pathology
Durapatite / chemistry*, toxicity
Lipids / chemistry
Platelet Aggregation Inhibitors / administration & dosage
Sirolimus / administration & dosage*
Ticlopidine / administration & dosage, analogs & derivatives
Wound Healing / drug effects*
|0/Cardiovascular Agents; 0/Coated Materials, Biocompatible; 0/Lipids; 0/Platelet Aggregation Inhibitors; 12597-68-1/Stainless Steel; 91D9GV0Z28/Durapatite; A74586SNO7/clopidogrel; OM90ZUW7M1/Ticlopidine; R16CO5Y76E/Aspirin; W36ZG6FT64/Sirolimus|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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